Oxidative diversification of amino acids and peptides by small-molecule iron catalysis

Thomas J. Osberger, Donald C. Rogness, Jeffrey T. Kohrt, Antonia F. Stepan and M. Christina White ()
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Thomas J. Osberger: Roger Adams Laboratory, University of Illinois
Donald C. Rogness: Roger Adams Laboratory, University of Illinois
Jeffrey T. Kohrt: Pfizer Worldwide Research and Development, Groton Laboratories
Antonia F. Stepan: Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development
M. Christina White: Roger Adams Laboratory, University of Illinois

Nature, 2016, vol. 537, issue 7619, 214-219

Abstract: Two small-molecule iron catalysts are shown to be capable of facilitating the targeted C–H oxidative modification of amino acids and peptides with preservation of α-centre chirality (a challenging synthesis), producing a diverse range of amino acids and peptides.

Date: 2016
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DOI: 10.1038/nature18941

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