Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

Lin Tang, Tamer M. Gamal El-Din, Teresa M. Swanson, David C. Pryde, Todd Scheuer, Ning Zheng () and William A. Catterall ()
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Lin Tang: University of Washington
Tamer M. Gamal El-Din: University of Washington
Teresa M. Swanson: University of Washington
David C. Pryde: Curadev Pharma
Todd Scheuer: University of Washington
Ning Zheng: University of Washington
William A. Catterall: University of Washington

Nature, 2016, vol. 537, issue 7618, 117-121

Abstract: Calcium channel blockers are widely used to treat cardiovascular diseases; new structural studies uncover how two different types of calcium-channel blockers bind to the channel; the drugs bind in different locations, revealing different mechanisms of drug action.

Date: 2016
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DOI: 10.1038/nature19102

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