The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

Jonathan J. Kotzin, Sean P. Spencer, Sam J. McCright, Dinesh B. Uthaya Kumar, Magalie A. Collet, Walter K. Mowel, Ellen N. Elliott, Asli Uyar, Michelle A. Makiya, Margaret C. Dunagin, Christian C. D. Harman, Anthony T. Virtue, Stella Zhu, Will Bailis, Judith Stein, Cynthia Hughes, Arjun Raj, E. John Wherry, Loyal A. Goff, Amy D. Klion, John L. Rinn, Adam Williams (), Richard A. Flavell () and Jorge Henao-Mejia ()
Additional contact information
Jonathan J. Kotzin: University of Pennsylvania
Sean P. Spencer: University of Pennsylvania
Sam J. McCright: University of Pennsylvania
Dinesh B. Uthaya Kumar: The Jackson Laboratory for Genomic Medicine
Magalie A. Collet: The Jackson Laboratory for Genomic Medicine
Walter K. Mowel: University of Pennsylvania
Ellen N. Elliott: The Jackson Laboratory for Genomic Medicine
Asli Uyar: The Jackson Laboratory for Genomic Medicine
Michelle A. Makiya: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Margaret C. Dunagin: University of Pennsylvania
Christian C. D. Harman: Yale University School of Medicine
Anthony T. Virtue: University of Pennsylvania
Stella Zhu: The Jackson Laboratory for Genomic Medicine
Will Bailis: Yale University School of Medicine
Judith Stein: Yale University School of Medicine
Cynthia Hughes: Yale University School of Medicine
Arjun Raj: University of Pennsylvania
E. John Wherry: Institute for Immunology, Perelman School of Medicine, University of Pennsylvania
Loyal A. Goff: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University
Amy D. Klion: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
John L. Rinn: Biological and Biomedical Sciences, Harvard Medical School
Adam Williams: The Jackson Laboratory for Genomic Medicine
Richard A. Flavell: Yale University School of Medicine
Jorge Henao-Mejia: University of Pennsylvania

Nature, 2016, vol. 537, issue 7619, 239-243

Abstract: The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis.

Date: 2016
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DOI: 10.1038/nature19346

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