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2016, volume 533, articles 7604

Society must seize control of the antibiotics crisis pp. 439-439

Carlos Amábile-Cuevas

Scientific sceptics hit back after rebuke pp. 441-441

Chris Woolston

Three-person embryos may fail to vanquish mutant mitochondria pp. 445-446

Ewen Callaway

Next generation of carbon-monitoring satellites faces daunting hurdles pp. 446-447

Jeff Tollefson

Silicon quantum computers take shape in Australia pp. 448-449

Elizabeth Gibney

Myriad Genetics embroiled in breast-cancer data fight — again pp. 449-449

Erika Check Hayden

US law could increase postdoc pay — and shake up research system pp. 450-450

Heidi Ledford

US reviews plan to infect mosquitoes with bacteria to stop disease pp. 450-451

Emily Waltz

1,500 scientists lift the lid on reproducibility pp. 452-454

Monya Baker

The secret history of ancient toilets pp. 456-458

Chelsea Wald

Medical research: Time to think differently about diabetes pp. 459-461

Francesco Rubino

Physics: Invest in neutrino astronomy pp. 462-464

Spencer Klein

Archaeology: Soaked in history pp. 466-467

Andrew Robinson

Books in brief pp. 467-467

Barbara Kiser

Epidemiology: Chasing epidemics pp. 468-468

Tilli Tansey

Spend more on soil clean-up in China pp. 469-469

Yijun Yao

Use open data to curb Zika virus pp. 469-469

Marie-Paule Kieny, Vasee Moorthy and Daniela Bagozzi

Restoration: avoid arbitrary baselines pp. 469-469

Zia Mehrabi

Restoration: 'Garden of Eden' unrealistic pp. 469-469

Martin F. Breed, Andrew J. Lowe and Peter E. Mortimer

Shark-fin landing policy aids control pp. 469-469

Alexander Stein

Harry Kroto (1939–2016) pp. 470-470

James R. Heath and Robert F. Curl

Choreography of protein synthesis pp. 472-473

Martin Ott

How black holes restrain old galaxies pp. 473-474

Marc Sarzi

Killer enzymes tethered pp. 475-476

Shigekazu Nagata

The bigger, the better pp. 476-476

Jennifer R. Gardiner

Ketamine steps out of the darkness pp. 477-478

Roberto Malinow

Unexpected player in particle formation pp. 478-479

Chris Cappa

NMDAR inhibition-independent antidepressant actions of ketamine metabolites pp. 481-486

Panos Zanos, Ruin Moaddel, Patrick J. Morris, Polymnia Georgiou, Jonathan Fischell, Greg I. Elmer, Manickavasagom Alkondon, Peixiong Yuan, Heather J. Pribut, Nagendra S. Singh, Katina S. S. Dossou, Yuhong Fang, Xi-Ping Huang, Cheryl L. Mayo, Irving W. Wainer, Edson X. Albuquerque, Scott M. Thompson, Craig J. Thomas, Carlos A. Zarate and Todd D. Gould

Tracing haematopoietic stem cell formation at single-cell resolution pp. 487-492

Fan Zhou, Xianlong Li, Weili Wang, Ping Zhu, Jie Zhou, Wenyan He, Meng Ding, Fuyin Xiong, Xiaona Zheng, Zhuan Li, Yanli Ni, Xiaohuan Mu, Lu Wen, Tao Cheng, Yu Lan, Weiping Yuan, Fuchou Tang and Bing Liu

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer pp. 493-498

Qing Chen, Adrienne Boire, Xin Jin, Manuel Valiente, Ekrem Emrah Er, Alejandro Lopez-Soto, Leni S. Jacob, Ruzeen Patwa, Hardik Shah, Ke Xu, Justin R. Cross and Joan Massagué

Synchronized mitochondrial and cytosolic translation programs pp. 499-503

Mary T. Couvillion, Iliana C. Soto, Gergana Shipkovenska and L. Stirling Churchman

Suppressing star formation in quiescent galaxies with supermassive black hole winds pp. 504-508

Edmond Cheung, Kevin Bundy, Michele Cappellari, Sébastien Peirani, Wiphu Rujopakarn, Kyle Westfall, Renbin Yan, Matthew Bershady, Jenny E. Greene, Timothy M. Heckman, Niv Drory, David R. Law, Karen L. Masters, Daniel Thomas, David A. Wake, Anne-Marie Weijmans, Kate Rubin, Francesco Belfiore, Benedetta Vulcani, Yan-mei Chen, Kai Zhang, Joseph D. Gelfand, Dmitry Bizyaev, A. Roman-Lopes and Donald P. Schneider

A resonant chain of four transiting, sub-Neptune planets pp. 509-512

Sean M. Mills, Daniel C. Fabrycky, Cezary Migaszewski, Eric B. Ford, Erik Petigura and Howard Isaacson

A high-temperature ferromagnetic topological insulating phase by proximity coupling pp. 513-516

Ferhat Katmis, Valeria Lauter, Flavio S. Nogueira, Badih A. Assaf, Michelle E. Jamer, Peng Wei, Biswarup Satpati, John W. Freeland, Ilya Eremin, Don Heiman, Pablo Jarillo-Herrero and Jagadeesh S. Moodera

Continuous probing of cold complex molecules with infrared frequency comb spectroscopy pp. 517-520

Ben Spaun, P. Bryan Changala, David Patterson, Bryce J. Bjork, Oliver H. Heckl, John M. Doyle and Jun Ye

Ion-induced nucleation of pure biogenic particles pp. 521-526

Jasper Kirkby, Jonathan Duplissy, Kamalika Sengupta, Carla Frege, Hamish Gordon, Christina Williamson, Martin Heinritzi, Mario Simon, Chao Yan, João Almeida, Jasmin Tröstl, Tuomo Nieminen, Ismael K. Ortega, Robert Wagner, Alexey Adamov, Antonio Amorim, Anne-Kathrin Bernhammer, Federico Bianchi, Martin Breitenlechner, Sophia Brilke, Xuemeng Chen, Jill Craven, Antonio Dias, Sebastian Ehrhart, Richard C. Flagan, Alessandro Franchin, Claudia Fuchs, Roberto Guida, Jani Hakala, Christopher R. Hoyle, Tuija Jokinen, Heikki Junninen, Juha Kangasluoma, Jaeseok Kim, Manuel Krapf, Andreas Kürten, Ari Laaksonen, Katrianne Lehtipalo, Vladimir Makhmutov, Serge Mathot, Ugo Molteni, Antti Onnela, Otso Peräkylä, Felix Piel, Tuukka Petäjä, Arnaud P. Praplan, Kirsty Pringle, Alexandru Rap, Nigel A. D. Richards, Ilona Riipinen, Matti P. Rissanen, Linda Rondo, Nina Sarnela, Siegfried Schobesberger, Catherine E. Scott, John H. Seinfeld, Mikko Sipilä, Gerhard Steiner, Yuri Stozhkov, Frank Stratmann, Antonio Tomé, Annele Virtanen, Alexander L. Vogel, Andrea C. Wagner, Paul E. Wagner, Ernest Weingartner, Daniela Wimmer, Paul M. Winkler, Penglin Ye, Xuan Zhang, Armin Hansel, Josef Dommen, Neil M. Donahue, Douglas R. Worsnop, Urs Baltensperger, Markku Kulmala, Kenneth S. Carslaw and Joachim Curtius

The role of low-volatility organic compounds in initial particle growth in the atmosphere pp. 527-531

Jasmin Tröstl, Wayne K. Chuang, Hamish Gordon, Martin Heinritzi, Chao Yan, Ugo Molteni, Lars Ahlm, Carla Frege, Federico Bianchi, Robert Wagner, Mario Simon, Katrianne Lehtipalo, Christina Williamson, Jill S. Craven, Jonathan Duplissy, Alexey Adamov, Joao Almeida, Anne-Kathrin Bernhammer, Martin Breitenlechner, Sophia Brilke, Antònio Dias, Sebastian Ehrhart, Richard C. Flagan, Alessandro Franchin, Claudia Fuchs, Roberto Guida, Martin Gysel, Armin Hansel, Christopher R. Hoyle, Tuija Jokinen, Heikki Junninen, Juha Kangasluoma, Helmi Keskinen, Jaeseok Kim, Manuel Krapf, Andreas Kürten, Ari Laaksonen, Michael Lawler, Markus Leiminger, Serge Mathot, Ottmar Möhler, Tuomo Nieminen, Antti Onnela, Tuukka Petäjä, Felix M. Piel, Pasi Miettinen, Matti P. Rissanen, Linda Rondo, Nina Sarnela, Siegfried Schobesberger, Kamalika Sengupta, Mikko Sipilä, James N. Smith, Gerhard Steiner, Antònio Tomè, Annele Virtanen, Andrea C. Wagner, Ernest Weingartner, Daniela Wimmer, Paul M. Winkler, Penglin Ye, Kenneth S. Carslaw, Joachim Curtius, Josef Dommen, Jasper Kirkby, Markku Kulmala, Ilona Riipinen, Douglas R. Worsnop, Neil M. Donahue and Urs Baltensperger

Competitive growth in a cooperative mammal pp. 532-534

Elise Huchard, Sinead English, Matt B. V. Bell, Nathan Thavarajah and Tim Clutton-Brock

How sexual selection can drive the evolution of costly sperm ornamentation pp. 535-538

Stefan Lüpold, Mollie K. Manier, Nalini Puniamoorthy, Christopher Schoff, William T. Starmer, Shannon H. Buckley Luepold, John M. Belote and Scott Pitnick

Genome-wide association study identifies 74 loci associated with educational attainment pp. 539-542

Aysu Okbay, Jonathan P. Beauchamp, Mark Alan Fontana, James J. Lee, Tune H. Pers, Cornelius A. Rietveld, Patrick Turley, Guo-Bo Chen, Valur Emilsson, S. Fleur W. Meddens, Sven Oskarsson, Joseph K. Pickrell, Kevin Thom, Pascal Timshel, Ronald de Vlaming, Abdel Abdellaoui, Tarunveer S. Ahluwalia, Jonas Bacelis, Clemens Baumbach, Gyda Bjornsdottir, Johannes H. Brandsma, Maria Pina Concas, Jaime Derringer, Nicholas A. Furlotte, Tessel E. Galesloot, Giorgia Girotto, Richa Gupta, Leanne M. Hall, Sarah E. Harris, Edith Hofer, Momoko Horikoshi, Jennifer E. Huffman, Kadri Kaasik, Ioanna P. Kalafati, Robert Karlsson, Augustine Kong, Jari Lahti, Sven J. van der Lee, Christiaan deLeeuw, Penelope A. Lind, Karl-Oskar Lindgren, Tian Liu, Massimo Mangino, Jonathan Marten, Evelin Mihailov, Michael B. Miller, Peter J. van der Most, Christopher Oldmeadow, Antony Payton, Natalia Pervjakova, Wouter J. Peyrot, Yong Qian, Olli Raitakari, Rico Rueedi, Erika Salvi, Börge Schmidt, Katharina E. Schraut, Jianxin Shi, Albert V. Smith, Raymond A. Poot, Beate St Pourcain, Alexander Teumer, Gudmar Thorleifsson, Niek Verweij, Dragana Vuckovic, Juergen Wellmann, Harm-Jan Westra, Jingyun Yang, Wei Zhao, Zhihong Zhu, Behrooz Z. Alizadeh, Najaf Amin, Andrew Bakshi, Sebastian E. Baumeister, Ginevra Biino, Klaus Bønnelykke, Patricia A. Boyle, Harry Campbell, Francesco P. Cappuccio, Gail Davies, Jan-Emmanuel De Neve, Panos Deloukas, Ilja Demuth, Jun Ding, Peter Eibich, Lewin Eisele, Niina Eklund, David M. Evans, Jessica D. Faul, Mary F. Feitosa, Andreas J. Forstner, Ilaria Gandin, Bjarni Gunnarsson, Bjarni V. Halldórsson, Tamara B. Harris, Andrew C. Heath, Lynne J. Hocking, Elizabeth G. Holliday, Georg Homuth, Michael A. Horan, Jouke-Jan Hottenga, Philip L. de Jager, Peter K. Joshi, Astanand Jugessur, Marika A. Kaakinen, Mika Kähönen, Stavroula Kanoni, Liisa Keltigangas-Järvinen, Lambertus A. L. M. Kiemeney, Ivana Kolcic, Seppo Koskinen, Aldi T. Kraja, Martin Kroh, Zoltan Kutalik, Antti Latvala, Lenore J. Launer, Maël P. Lebreton, Douglas F. Levinson, Paul Lichtenstein, Peter Lichtner, David C. M. Liewald, LifeLines Cohort Study, Anu Loukola, Pamela A. Madden, Reedik Mägi, Tomi Mäki-Opas, Riccardo E. Marioni, Pedro Marques-Vidal, Gerardus A. Meddens, George McMahon, Christa Meisinger, Thomas Meitinger, Yusplitri Milaneschi, Lili Milani, Grant W. Montgomery, Ronny Myhre, Christopher P. Nelson, Dale R. Nyholt, William E. R. Ollier, Aarno Palotie, Lavinia Paternoster, Nancy L. Pedersen, Katja E. Petrovic, David J. Porteous, Katri Räikkönen, Susan M. Ring, Antonietta Robino, Olga Rostapshova, Igor Rudan, Aldo Rustichini, Veikko Salomaa, Alan R. Sanders, Antti-Pekka Sarin, Helena Schmidt, Rodney J. Scott, Blair H. Smith, Jennifer A. Smith, Jan A. Staessen, Elisabeth Steinhagen-Thiessen, Konstantin Strauch, Antonio Terracciano, Martin D. Tobin, Sheila Ulivi, Simona Vaccargiu, Lydia Quaye, Frank J. A. van Rooij, Cristina Venturini, Anna A. E. Vinkhuyzen, Uwe Völker, Henry Völzke, Judith M. Vonk, Diego Vozzi, Johannes Waage, Erin B. Ware, Gonneke Willemsen, John R. Attia, David A. Bennett, Klaus Berger, Lars Bertram, Hans Bisgaard, Dorret I. Boomsma, Ingrid B. Borecki, Ute Bültmann, Christopher F. Chabris, Francesco Cucca, Daniele Cusi, Ian J. Deary, George V. Dedoussis, Cornelia M. van Duijn, Johan G. Eriksson, Barbara Franke, Lude Franke, Paolo Gasparini, Pablo V. Gejman, Christian Gieger, Hans-Jörgen Grabe, Jacob Gratten, Patrick Groenen, Vilmundur Gudnason, Pim van der Harst, Caroline Hayward, David A. Hinds, Wolfgang Hoffmann, Elina Hyppönen, William G. Iacono, Bo Jacobsson, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L. R. Kardia, Terho Lehtimäki, Steven Lehrer, Patrik K. E. Magnusson, Nicholas G. Martin, Matt McGue, Andres Metspalu, Neil Pendleton, Brenda W. J. H. Penninx, Markus Perola, Nicola Pirastu, Mario Pirastu, Ozren Polasek, Danielle Posthuma, Christine Power, Michael A. Province, Nilesh J. Samani, David Schlessinger, Reinhold Schmidt, Thorkild I. A. Sørensen, Tim D. Spector, Kari Stefansson, Unnur Thorsteinsdottir, Roy Thurik, Nicholas J. Timpson, Henning Tiemeier, Joyce Y. Tung, André G. Uitterlinden, Veronique Vitart, Peter Vollenweider, David R. Weir, James F. Wilson, Alan F. Wright, Dalton C. Conley, Robert F. Krueger, George Davey Smith, Albert Hofman, David Laibson, Sarah E. Medland, Michelle N. Meyer, Jian Yang, Magnus Johannesson, Peter M. Visscher, Tõnu Esko, Philipp D. Koellinger, David Cesarini and Daniel J. Benjamin

Culturing of ‘unculturable’ human microbiota reveals novel taxa and extensive sporulation pp. 543-546

Hilary P. Browne, Samuel C. Forster, Blessing O. Anonye, Nitin Kumar, B. Anne Neville, Mark D. Stares, David Goulding and Trevor D. Lawley

Redirecting abiraterone metabolism to fine-tune prostate cancer anti-androgen therapy pp. 547-551

Zhenfei Li, Mohammad Alyamani, Jianneng Li, Kevin Rogacki, Mohamed Abazeed, Sunil K. Upadhyay, Steven P. Balk, Mary-Ellen Taplin, Richard J. Auchus and Nima Sharifi

Access of protective antiviral antibody to neuronal tissues requires CD4 T-cell help pp. 552-556

Norifumi Iijima and Akiko Iwasaki

Structural insights into inhibition of lipid I production in bacterial cell wall synthesis pp. 557-560

Ben C. Chung, Ellene H. Mashalidis, Tetsuya Tanino, Mijung Kim, Akira Matsuda, Jiyong Hong, Satoshi Ichikawa and Seok-Yong Lee

Crystal structure of the human sterol transporter ABCG5/ABCG8 pp. 561-564

Jyh-Yeuan Lee, Lisa N. Kinch, Dominika M. Borek, Jin Wang, Junmei Wang, Ina L. Urbatsch, Xiao-Song Xie, Nikolai V. Grishin, Jonathan C. Cohen, Zbyszek Otwinowski, Helen H. Hobbs and Daniel M. Rosenbaum

Illuminating life's building blocks pp. 565-568

Marissa Fessenden

Education: Degrees of success pp. 569-570

Chris Woolston

Browsing pp. 572-572

Ian Whates

2016, volume 533, articles 7603

No observable conformational changes in PSII pp. E1-E2

Nicholas K. Sauter, Nathaniel Echols, Paul D. Adams, Petrus H. Zwart, Jan Kern, Aaron S. Brewster, Sergey Koroidov, Roberto Alonso-Mori, Athina Zouni, Johannes Messinger, Uwe Bergmann, Junko Yano and Vittal K. Yachandra

Irritable bowel syndrome pp. S101-S101

Michelle Grayson

Transit time pp. S102-S103

Amber Dance

Microbiome: Bacterial broadband pp. S104-S106

Michael Eisenstein

Perspective: An easier diagnosis pp. S107-S107

Brian E. Lacy

Diet: Food for thought pp. S108-S109

Sarah DeWeerdt

Diagnostics: Filling in the missing pieces pp. S110-S111

Alla Katsnelson

Q&A: Peter Whorwell pp. S112-S113

Helen Pilcher

Infectious disease: Something in the water pp. S114-S115

Sujata Gupta

Drug development: A healthy pipeline pp. S116-S117

Branwen Morgan

Irritable bowel syndrome: 4 big questions pp. S118-S118

Michelle Grayson

Teach students the biology of their time pp. 293-293

Gregory Radick

Researcher under fire for New Yorker epigenetics article pp. 295-295

Chris Woolston

Gridlock over Italy’s olive tree deaths starts to ease pp. 299-300

Alison Abbott

Demotion of science ministry angers beleaguered Brazilian researchers pp. 301-301

Claudio Angelo

Boaty McBoatfleet: British ship joins wave of rugged polar vessels pp. 302-303

Alexandra Witze

Mirror-image enzyme copies looking-glass DNA pp. 303-304

Mark Peplow

Bankruptcy filing worries developers of nanoparticle cancer drugs pp. 304-305

Heidi Ledford

Mixed-up metals make for stronger, tougher, stretchier alloys pp. 306-307

XiaoZhi Lim

The race to create super-crops pp. 308-310

Natasha Gilbert

Policy: Global standards for stem-cell research pp. 311-313

Jonathan Kimmelman, Insoo Hyun, Nissim Benvenisty, Timothy Caulfield, Helen E. Heslop, Charles E. Murry, Douglas Sipp, Lorenz Studer, Jeremy Sugarman and George Q. Daley

Twelve principles for open innovation 2.0 pp. 314-316

Martin Curley

Ecology: The sea-otter whisperer pp. 318-319

Jane Lubchenco

Books in brief pp. 319-319

Barbara Kiser

Arts: California on camera pp. 320-320

John Gilbey

Prevent misuse of eco-compensation pp. 321-321

Qinhua Fang and Michael Elliott

Speed publication of self-corrections pp. 321-321

Pamela Ronald

EU list should add potential invasives pp. 321-321

Maiju Lehtiniemi

Nicaragua Canal may not benefit shipping pp. 321-321

Jihong Chen and Xiang Liu

Clean up the air in Kathmandu pp. 321-321

Keshav Parajuly

Harry Elderfield (1943–2016) pp. 322-322

Rosalind E. M. Rickaby

Virtual reality explored pp. 324-325

Matthias Minderer, Christopher D. Harvey, Flavio Donato and Edvard I. Moser

Fighting evolution with chemical synthesis pp. 326-327

Ming Yan and Phil S. Baran

A deliberate mix-up in flavour pp. 327-328

Helen O'Keeffe

Limb regrowth takes two pp. 328-330

Miguel Torres

Illuminating brown dwarfs pp. 330-331

Adam P. Showman

Snapshots of transcription initiation pp. 331-332

Steven Hahn and Stephen Buratowski

Reproducible pharmacogenomic profiling of cancer cell line panels pp. 333-337

Peter M. Haverty, Eva Lin, Jenille Tan, Yihong Yu, Billy Lam, Steve Lianoglou, Richard M. Neve, Scott Martin, Jeff Settleman, Robert L. Yauch and Richard Bourgon

A platform for the discovery of new macrolide antibiotics pp. 338-345

Ian B. Seiple, Ziyang Zhang, Pavol Jakubec, Audrey Langlois-Mercier, Peter M. Wright, Daniel T. Hog, Kazuo Yabu, Senkara Rao Allu, Takehiro Fukuzaki, Peter N. Carlsen, Yoshiaki Kitamura, Xiang Zhou, Matthew L. Condakes, Filip T. Szczypiński, William D. Green and Andrew G. Myers

Structure of the T4 baseplate and its function in triggering sheath contraction pp. 346-352

Nicholas M. I. Taylor, Nikolai S. Prokhorov, Ricardo C. Guerrero-Ferreira, Mikhail M. Shneider, Christopher Browning, Kenneth N. Goldie, Henning Stahlberg and Petr G. Leiman

Transcription initiation complex structures elucidate DNA opening pp. 353-358

C. Plaschka, M. Hantsche, C. Dienemann, C. Burzinski, J. Plitzko and P. Cramer

Near-atomic resolution visualization of human transcription promoter opening pp. 359-365

Yuan He, Chunli Yan, Jie Fang, Carla Inouye, Robert Tjian, Ivaylo Ivanov and Eva Nogales

An irradiated brown-dwarf companion to an accreting white dwarf pp. 366-368

Juan V. Hernández Santisteban, Christian Knigge, Stuart P. Littlefair, Rene P. Breton, Vikram S. Dhillon, Boris T. Gänsicke, Thomas R. Marsh, Magaretha L. Pretorius, John Southworth and Peter H. Hauschildt

Self-assembly of coherently dynamic, auxetic, two-dimensional protein crystals pp. 369-373

Yuta Suzuki, Giovanni Cardone, David Restrepo, Pablo D. Zavattieri, Timothy S. Baker and F. Akif Tezcan

Iron(III)-catalysed carbonyl–olefin metathesis pp. 374-379

Jacob R. Ludwig, Paul M. Zimmerman, Joseph B. Gianino and Corinna S. Schindler

Changing atmospheric CO2 concentration was the primary driver of early Cenozoic climate pp. 380-384

Eleni Anagnostou, Eleanor H. John, Kirsty M. Edgar, Gavin L. Foster, Andy Ridgwell, Gordon N. Inglis, Richard D. Pancost, Daniel J. Lunt and Paul N. Pearson

Repeated large-scale retreat and advance of Totten Glacier indicated by inland bed erosion pp. 385-389

A. R. A. Aitken, J. L. Roberts, T. D. van Ommen, D. A. Young, N. R. Golledge, J. S. Greenbaum, D. D. Blankenship and M. J. Siegert

Metabolic acceleration and the evolution of human brain size and life history pp. 390-392

Herman Pontzer, Mary H. Brown, David A. Raichlen, Holly Dunsworth, Brian Hare, Kara Walker, Amy Luke, Lara R. Dugas, Ramon Durazo-Arvizu, Dale Schoeller, Jacob Plange-Rhule, Pascal Bovet, Terrence E. Forrester, Estelle V. Lambert, Melissa Emery Thompson, Robert W. Shumaker and Stephen R. Ross

Deep-sea diversity patterns are shaped by energy availability pp. 393-396

Skipton N. C. Woolley, Derek P. Tittensor, Piers K. Dunstan, Gurutzeta Guillera-Arroita, José J. Lahoz-Monfort, Brendan A. Wintle, Boris Worm and Timothy D. O’Hara

Local fitness landscape of the green fluorescent protein pp. 397-401

Karen S. Sarkisyan, Dmitry A. Bolotin, Margarita V. Meer, Dinara R. Usmanova, Alexander S. Mishin, George V. Sharonov, Dmitry N. Ivankov, Nina G. Bozhanova, Mikhail S. Baranov, Onuralp Soylemez, Natalya S. Bogatyreva, Peter K. Vlasov, Evgeny S. Egorov, Maria D. Logacheva, Alexey S. Kondrashov, Dmitry M. Chudakov, Ekaterina V. Putintseva, Ilgar Z. Mamedov, Dan S. Tawfik, Konstantin A. Lukyanov and Fyodor A. Kondrashov

Opponent and bidirectional control of movement velocity in the basal ganglia pp. 402-406

Eric A. Yttri and Joshua T. Dudman

FGF8 and SHH substitute for anterior–posterior tissue interactions to induce limb regeneration pp. 407-410

Eugeniu Nacu, Elena Gromberg, Catarina R. Oliveira, David Drechsel and Elly M. Tanaka

An obligatory role for neurotensin in high-fat-diet-induced obesity pp. 411-415

Jing Li, Jun Song, Yekaterina Y. Zaytseva, Yajuan Liu, Piotr Rychahou, Kai Jiang, Marlene E. Starr, Ji Tae Kim, Jennifer W. Harris, Frederique B. Yiannikouris, Wendy S. Katz, Peter M. Nilsson, Marju Orho-Melander, Jing Chen, Haining Zhu, Timothy Fahrenholz, Richard M. Higashi, Tianyan Gao, Andrew J. Morris, Lisa A. Cassis, Teresa W. -M. Fan, Heidi L. Weiss, Paul R. Dobner, Olle Melander, Jianhang Jia and B. Mark Evers

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response pp. 416-419

Yi-Fan Lin, Anna M. Schulz, Mark W. Pellegrino, Yun Lu, Shai Shaham and Cole M. Haynes

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage pp. 420-424

Alexis C. Komor, Yongjoo B. Kim, Michael S. Packer, John A. Zuris and David R. Liu

Structure of the thermally stable Zika virus pp. 425-428

Victor A. Kostyuchenko, Elisa X. Y. Lim, Shuijun Zhang, Guntur Fibriansah, Thiam-Seng Ng, Justin S. G. Ooi, Jian Shi and Shee-Mei Lok

Relationships: Doctor's advice pp. 429-430

Alaina Levine

Trade talk: Cell negotiator pp. 430-430

Monya Baker

Project Earth is leaving beta pp. 432-432

J.W. Alden

2016, volume 533, articles 7602

Open innovation pp. S53-S53

Richard Hodson

A new chapter in innovation pp. S54-S55

David Holmes

Competition: Unlikely partnerships pp. S56-S58

Neil Savage

Q&A: Bernard Munos pp. S59-S59

Eric Bender

Chemical probes: A shared toolbox pp. S60-S61

Andrew R. Scott

Challenges: Crowdsourced solutions pp. S62-S64

Eric Bender

Compound screening: Fresh hunting ground pp. S65-S67

Annabel McGilvray

Tropical disease: A neglected cause pp. S68-S69

Lucas Laursen

Perspective: Science is still too closed pp. S70-S70

Aled Edwards

Data sharing: Access all areas pp. S71-S72

Brian Owens

The pressure to publish pushes down quality pp. 147-147

Daniel Sarewitz

Higgs Bison or Niels Bohrson? Twitter offers names for Fermilab’s baby bison pp. 149-149

Chris Woolston

Low-cost headsets boost virtual reality’s lab appeal pp. 153-154

Davide Castelvecchi

Gene variants linked to success at school prove divisive pp. 154-155

Erika Check Hayden

Intricate animal and flower tattoos found on Egyptian mummy pp. 155-155

Traci Watson

Biologists struggle with push to eliminate radioactive caesium in labs pp. 156-157

Jeff Tollefson

France’s research minister lays out his priorities pp. 157-158

Declan Butler

Row over proposed Italian biomedical centre intensifies pp. 158-159

Alison Abbott

The spectrum of sex development: Eric Vilain and the intersex controversy pp. 160-163

Sara Reardon

How to hack the hackers: The human side of cybercrime pp. 164-167

M. Mitchell Waldrop

Embryology policy: Revisit the 14-day rule pp. 169-171

Insoo Hyun, Amy Wilkerson and Josephine Johnston

Natural history: Restore our sense of species pp. 172-174

Klaas-Douwe B. Dijkstra

History: A chemist's contradictions pp. 175-176

Mark Peplow

Biodiversity: England's green and well-known land pp. 176-177

Stuart Pimm

Genetics: On the heredity trail pp. 178-178

Matthew Cobb

Reminder to deposit DNA sequences pp. 179-179

Steven L. Salzberg

El Niño dons winter disguise as La Niña pp. 179-179

Judah Cohen

Reform oversight of Italy's science funds pp. 179-179

Ernesto Carafoli and Cesare Montecucco

Regulate devices for brain stimulation pp. 179-179

Olivia Carter and Jason Forte

Implantation barrier overcome pp. 182-183

Janet Rossant

Precision pruning of molecules pp. 183-184

Kin S. Yang and Keary M. Engle

Ancient air caught by shooting stars pp. 184-186

Kevin Zahnle and Roger Buick

Quasiparticles on a collision course pp. 186-187

Dirk van der Marel

Fresh solutions to the four-body problem pp. 187-188

Douglas P. Hamilton

Wired for sex pp. 188-189

Douglas S. Portman

Palaeoclimatic insights into forcing and response of monsoon rainfall pp. 191-199

Mahyar Mohtadi, Matthias Prange and Stephan Steinke

The Atlantic salmon genome provides insights into rediploidization pp. 200-205

Sigbjørn Lien, Ben F. Koop, Simen R. Sandve, Jason R. Miller, Matthew P. Kent, Torfinn Nome, Torgeir R. Hvidsten, Jong S. Leong, David R. Minkley, Aleksey Zimin, Fabian Grammes, Harald Grove, Arne Gjuvsland, Brian Walenz, Russell A. Hermansen, Kris von Schalburg, Eric B. Rondeau, Alex Di Genova, Jeevan K. A. Samy, Jon Olav Vik, Magnus D. Vigeland, Lis Caler, Unni Grimholt, Sissel Jentoft, Dag Inge Våge, Pieter de Jong, Thomas Moen, Matthew Baranski, Yniv Palti, Douglas R. Smith, James A. Yorke, Alexander J. Nederbragt, Ave Tooming-Klunderud, Kjetill S. Jakobsen, Xuanting Jiang, Dingding Fan, Yan Hu, David A. Liberles, Rodrigo Vidal, Patricia Iturra, Steven J. M. Jones, Inge Jonassen, Alejandro Maass, Stig W. Omholt and William S. Davidson

Sex-specific pruning of neuronal synapses in Caenorhabditis elegans pp. 206-211

Meital Oren-Suissa, Emily A. Bayer and Oliver Hobert

Interconnected microbiomes and resistomes in low-income human habitats pp. 212-216

Erica C. Pehrsson, Pablo Tsukayama, Sanket Patel, Melissa Mejía-Bautista, Giordano Sosa-Soto, Karla M. Navarrete, Maritza Calderon, Lilia Cabrera, William Hoyos-Arango, M. Teresita Bertoli, Douglas E. Berg, Robert H. Gilman and Gautam Dantas

No Sun-like dynamo on the active star ζ Andromedae from starspot asymmetry pp. 217-220

R. M. Roettenbacher, J. D. Monnier, H. Korhonen, A. N. Aarnio, F. Baron, X. Che, R. O. Harmon, Zs. Kővári, S. Kraus, G. H. Schaefer, G. Torres, M. Zhao, T. A. ten Brummelaar, J. Sturmann and L. Sturmann

Temperate Earth-sized planets transiting a nearby ultracool dwarf star pp. 221-224

Michaël Gillon, Emmanuël Jehin, Susan M. Lederer, Laetitia Delrez, Julien de Wit, Artem Burdanov, Valérie Van Grootel, Adam J. Burgasser, Amaury H. M. J. Triaud, Cyrielle Opitom, Brice-Olivier Demory, Devendra K. Sahu, Daniella Bardalez Gagliuffi, Pierre Magain and Didier Queloz

Lightwave-driven quasiparticle collisions on a subcycle timescale pp. 225-229

F. Langer, M. Hohenleutner, C. P. Schmid, C. Poellmann, P. Nagler, T. Korn, C. Schüller, M. S. Sherwin, U. Huttner, J. T. Steiner, S. W. Koch, M. Kira and R. Huber

Site-selective and stereoselective functionalization of unactivated C–H bonds pp. 230-234

Kuangbiao Liao, Solymar Negretti, Djamaladdin G. Musaev, John Bacsa and Huw M. L. Davies

Ancient micrometeorites suggestive of an oxygen-rich Archaean upper atmosphere pp. 235-238

Andrew G. Tomkins, Lara Bowlt, Matthew Genge, Sasha Wilson, Helen E. A. Brand and Jeremy L. Wykes

A rapid burst in hotspot motion through the interaction of tectonics and deep mantle flow pp. 239-242

Rakib Hassan, R. Dietmar Müller, Michael Gurnis, Simon E. Williams and Nicolas Flament

First North American fossil monkey and early Miocene tropical biotic interchange pp. 243-246

Jonathan I. Bloch, Emily D. Woodruff, Aaron R. Wood, Aldo F. Rincon, Arianna R. Harrington, Gary S. Morgan, David A. Foster, Camilo Montes, Carlos A. Jaramillo, Nathan A. Jud, Douglas S. Jones and Bruce J. MacFadden

Restoring cortical control of functional movement in a human with quadriplegia pp. 247-250

Chad E. Bouton, Ammar Shaikhouni, Nicholas V. Annetta, Marcia A. Bockbrader, David A. Friedenberg, Dylan M. Nielson, Gaurav Sharma, Per B. Sederberg, Bradley C. Glenn, W. Jerry Mysiw, Austin G. Morgan, Milind Deogaonkar and Ali R. Rezai

Self-organization of the in vitro attached human embryo pp. 251-254

Alessia Deglincerti, Gist F. Croft, Lauren N. Pietila, Magdalena Zernicka-Goetz, Eric D. Siggia and Ali H. Brivanlou

The evolution of cooperation within the gut microbiota pp. 255-259

Seth Rakoff-Nahoum, Kevin R. Foster and Laurie E. Comstock

Molecular mechanism of APC/C activation by mitotic phosphorylation pp. 260-264

Suyang Zhang, Leifu Chang, Claudio Alfieri, Ziguo Zhang, Jing Yang, Sarah Maslen, Mark Skehel and David Barford

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection pp. 265-268

Libin Ye, Ned Van Eps, Marco Zimmer, Oliver P. Ernst and R. Scott Prosser

Architecture of the mitochondrial calcium uniporter pp. 269-273

Kirill Oxenoid, Ying Dong, Chan Cao, Tanxing Cui, Yasemin Sancak, Andrew L. Markhard, Zenon Grabarek, Liangliang Kong, Zhijun Liu, Bo Ouyang, Yao Cong, Vamsi K. Mootha and James J. Chou

Extra-helical binding site of a glucagon receptor antagonist pp. 274-277

Ali Jazayeri, Andrew S. Doré, Daniel Lamb, Harini Krishnamurthy, Stacey M. Southall, Asma H. Baig, Andrea Bortolato, Markus Koglin, Nathan J. Robertson, James C. Errey, Stephen P. Andrews, Iryna Teobald, Alastair J. H. Brown, Robert M. Cooke, Malcolm Weir and Fiona H. Marshall

Correction: Corrigendum: Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis pp. 278-278

Shidong Jia, Zhenning Liu, Sen Zhang, Pixu Liu, Lei Zhang, Sang Hyun Lee, Jing Zhang, Sabina Signoretti, Massimo Loda, Thomas M. Roberts and Jean J. Zhao

Correction: Corrigendum: Structural and functional features of central nervous system lymphatic vessels pp. 278-278

Antoine Louveau, Igor Smirnov, Timothy J. Keyes, Jacob D. Eccles, Sherin J. Rouhani, J. David Peske, Noel C. Derecki, David Castle, James W. Mandell, Kevin S. Lee, Tajie H. Harris and Jonathan Kipnis

Correction: Corrigendum: Bees prefer foods containing neonicotinoid pesticides pp. 278-278

Sébastien C. Kessler, Erin Jo Tiedeken, Kerry L. Simcock, Sophie Derveau, Jessica Mitchell, Samantha Softley, Amy Radcliffe, Jane C. Stout and Geraldine A. Wright

Peer review: Close inspection pp. 279-281

Quirin Schiermeier

Turning point: Intelligence programmer pp. 281-281

Virginia Gewin

Venice, Version 9.0 pp. 284-284

Preston Grassmann

2016, volume 533, articles 7601

Research commercialization pp. S5-S5

Herb Brody

Cashing in on science pp. S6-S7

Alla Katsnelson

Set up a public registry of competing interests pp. 9-9

Adam G. Dunn

Start-ups: A sense of enterprise pp. S10-S12

Neil Savage

Technology transfer: The leap to industry pp. S13-S15

Jessica Wapner

Human embryos grown in lab for longer than ever before pp. 15-16

Sara Reardon

Australia softens blow of climate job cuts pp. 16-17

Myles Gough

Software error doomed Japanese Hitomi spacecraft pp. 18-19

Alexandra Witze

US and China eye up European gravitational-wave mission pp. 19-19

Elizabeth Gibney

Assessment: Academic return pp. S20-S21

Michael Eisenstein

Stem-cell plan aims to bring rhino back from brink of extinction pp. 20-21

Ewen Callaway

Australia: Engagement upgrade pp. S22-S23

Bianca Nogrady

Can artificial intelligence create the next wonder material? pp. 22-25

Nicola Nosengo

Nine years of censorship pp. 26-28

Lesley Evans Ogden

Policy: Security spending must cover disease outbreaks pp. 29-31

Tadataka Yamada, V. Ayano Ogawa and Maria Freire

Q&A: Horst Domdey pp. S30-S31

Chelsea Wald

Ethology: Intrepid translator of the hive pp. 32-33

Mark L. Winston

China: Building an innovator pp. S32-S33

Nicky Phillips

Books in brief pp. 33-33

Barbara Kiser

Physics: Material to meaning pp. 34-34

Robert P. Crease

Curb anchor scour for green shipping pp. 36-36

Andrew R. Davis and Allison Broad

Renewables targeted before Fukushima pp. 36-36

Aleh Cherp and Jessica Jewell

Debate over whale longevity is futile pp. 36-36

P. J. Nico de Bruyn

Shared goals score reproducible results pp. 36-36

Eric Buenz

Clockwork at the atomic scale pp. 38-39

Marjana Ležaić

Evolved to overcome Bt-toxin resistance pp. 39-40

Daniel Dovrat and Amir Aharoni

Guilt by genetic association pp. 40-41

Asa Abeliovich and Herve Rhinn

Collaboration: The geography of discovery pp. S40-S42

Emily Sohn

Mum's microbes boost baby's immunity pp. 42-43

Mihir Pendse and Lora V. Hooper

Funding: Donor drugs pp. S43-S45

Cassandra Willyard

Ubiquitination without E1 and E2 enzymes pp. 43-44

Sagar Bhogaraju and Ivan Dikic

Elusive transition spotted in thorium pp. 44-45

Marianna Safronova

Direct detection of the 229Th nuclear clock transition pp. 47-51

Lars von der Wense, Benedict Seiferle, Mustapha Laatiaoui, Jürgen B. Neumayr, Hans-Jörg Maier, Hans-Friedrich Wirth, Christoph Mokry, Jörg Runke, Klaus Eberhardt, Christoph E. Düllmann, Norbert G. Trautmann and Peter G. Thirolf

Q&A: Helga Nowotny pp. S47-S47

Chelsea Wald

Principles underlying sensory map topography in primary visual cortex pp. 52-57

Jens Kremkow, Jianzhong Jin, Yushi Wang and Jose M. Alonso

Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance pp. 58-63

Ahmed H. Badran, Victor M. Guzov, Qing Huai, Melissa M. Kemp, Prashanth Vishwanath, Wendy Kain, Autumn M. Nance, Artem Evdokimov, Farhad Moshiri, Keith H. Turner, Ping Wang, Thomas Malvar and David R. Liu

Resolved atomic lines reveal outflows in two ultraluminous X-ray sources pp. 64-67

Ciro Pinto, Matthew J. Middleton and Andrew C. Fabian

Polar metals by geometric design pp. 68-72

T. H. Kim, D. Puggioni, Y. Yuan, L. Xie, H. Zhou, N. Campbell, P. J. Ryan, Y. Choi, J.-W. Kim, J. R. Patzner, S. Ryu, J. P. Podkaminer, J. Irwin, Y. Ma, C. J. Fennie, M. S. Rzchowski, X. Q. Pan, V. Gopalan, J. M. Rondinelli and C. B. Eom

Machine-learning-assisted materials discovery using failed experiments pp. 73-76

Paul Raccuglia, Katherine C. Elbert, Philip D. F. Adler, Casey Falk, Malia B. Wenny, Aurelio Mollo, Matthias Zeller, Sorelle A. Friedler, Joshua Schrier and Alexander J. Norquist

Scalable and sustainable electrochemical allylic C–H oxidation pp. 77-81

Evan J. Horn, Brandon R. Rosen, Yong Chen, Jiaze Tang, Ke Chen, Martin D. Eastgate and Phil S. Baran

Chondritic xenon in the Earth’s mantle pp. 82-85

Antonio Caracausi, Guillaume Avice, Peter G. Burnard, Evelyn Füri and Bernard Marty

The genetic program for cartilage development has deep homology within Bilateria pp. 86-89

Oscar A. Tarazona, Leslie A. Slota, Davys H. Lopez, GuangJun Zhang and Martin J. Cohn

Topology of ON and OFF inputs in visual cortex enables an invariant columnar architecture pp. 90-94

Kuo-Sheng Lee, Xiaoying Huang and David Fitzpatrick

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression pp. 95-99

Frank Soldner, Yonatan Stelzer, Chikdu S. Shivalila, Brian J. Abraham, Jeanne C. Latourelle, M. Inmaculada Barrasa, Johanna Goldmann, Richard H. Myers, Richard A. Young and Rudolf Jaenisch

Unique human immune signature of Ebola virus disease in Guinea pp. 100-104

Paula Ruibal, Lisa Oestereich, Anja Lüdtke, Beate Becker-Ziaja, David M. Wozniak, Romy Kerber, Miša Korva, Mar Cabeza-Cabrerizo, Joseph A. Bore, Fara Raymond Koundouno, Sophie Duraffour, Romy Weller, Anja Thorenz, Eleonora Cimini, Domenico Viola, Chiara Agrati, Johanna Repits, Babak Afrough, Lauren A. Cowley, Didier Ngabo, Julia Hinzmann, Marc Mertens, Inês Vitoriano, Christopher H. Logue, Jan Peter Boettcher, Elisa Pallasch, Andreas Sachse, Amadou Bah, Katja Nitzsche, Eeva Kuisma, Janine Michel, Tobias Holm, Elsa-Gayle Zekeng, Isabel García-Dorival, Roman Wölfel, Kilian Stoecker, Erna Fleischmann, Thomas Strecker, Antonino Di Caro, Tatjana Avšič-Županc, Andreas Kurth, Silvia Meschi, Stephane Mély, Edmund Newman, Anne Bocquin, Zoltan Kis, Anne Kelterbaum, Peter Molkenthin, Fabrizio Carletti, Jasmine Portmann, Svenja Wolff, Concetta Castilletti, Gordian Schudt, Alexandra Fizet, Lisa J. Ottowell, Eva Herker, Thomas Jacobs, Birte Kretschmer, Ettore Severi, Nobila Ouedraogo, Mar Lago, Anabel Negredo, Leticia Franco, Pedro Anda, Stefan Schmiedel, Benno Kreuels, Dominic Wichmann, Marylyn M. Addo, Ansgar W. Lohse, Hilde De Clerck, Carolina Nanclares, Sylvie Jonckheere, Michel Van Herp, Armand Sprecher, Gao Xiaojiang, Mary Carrington, Osvaldo Miranda, Carlos M. Castro, Martin Gabriel, Patrick Drury, Pierre Formenty, Boubacar Diallo, Lamine Koivogui, N’Faly Magassouba, Miles W. Carroll, Stephan Günther and César Muñoz-Fontela

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges pp. 105-109

Rajeev Gautam, Yoshiaki Nishimura, Amarendra Pegu, Martha C. Nason, Florian Klein, Anna Gazumyan, Jovana Golijanin, Alicia Buckler-White, Reza Sadjadpour, Keyun Wang, Zachary Mankoff, Stephen D. Schmidt, Jeffrey D. Lifson, John R. Mascola, Michel C. Nussenzweig and Malcolm A. Martin

EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells pp. 110-114

Jianhua Li, Erick Lu, Tangsheng Yi and Jason G. Cyster

RETRACTED ARTICLE: Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells pp. 115-119

Jennifer Martinez, Larissa D. Cunha, Sunmin Park, Mao Yang, Qun Lu, Robert Orchard, Quan-Zhen Li, Mei Yan, Laura Janke, Cliff Guy, Andreas Linkermann, Herbert W. Virgin and Douglas R. Green

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors pp. 120-124

Jiazhang Qiu, Michael J. Sheedlo, Kaiwen Yu, Yunhao Tan, Ernesto S. Nakayasu, Chittaranjan Das, Xiaoyun Liu and Zhao-Qing Luo

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9 pp. 125-129

Dominik Paquet, Dylan Kwart, Antonia Chen, Andrew Sproul, Samson Jacob, Shaun Teo, Kimberly Moore Olsen, Andrew Gregg, Scott Noggle and Marc Tessier-Lavigne

Correction: Corrigendum: Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans pp. 130-130

Sreekanth H. Chalasani, Nikos Chronis, Makoto Tsunozaki, Jesse M. Gray, Daniel Ramot, Miriam B. Goodman and Cornelia I. Bargmann

Correction: Corrigendum: Discovery of Atg5/Atg7-independent alternative macroautophagy pp. 130-130

Yuya Nishida, Satoko Arakawa, Kenji Fujitani, Hirofumi Yamaguchi, Takeshi Mizuta, Toku Kanaseki, Masaaki Komatsu, Kinya Otsu, Yoshihide Tsujimoto and Shigeomi Shimizu

Correction: Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions pp. 130-130

Wendy Huang, Benjamin Thomas, Ryan A. Flynn, Samuel J. Gavzy, Lin Wu, Sangwon V. Kim, Jason A. Hall, Emily R. Miraldi, Charles P. Ng, Frank Rigo, Sarah Meadows, Nina R. Montoya, Natalia G. Herrera, Ana I. Domingos, Fraydoon Rastinejad, Richard M. Myers, Frances V. Fuller-Pace, Richard Bonneau, Howard Y. Chang, Oreste Acuto and Dan R. Littman

The struggle with image glut pp. 131-132

Jeffrey M. Perkel

Relationships: Scions of science pp. 133-135

Amber Dance

The Museum of Nothing pp. 138-138

Anna Zumbro