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Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

Li He (), Guangwei Si, Jiuhong Huang, Aravinthan D. T. Samuel and Norbert Perrimon ()
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Li He: Harvard Medical School
Guangwei Si: Center for Brain Science, Harvard University
Jiuhong Huang: School of Life Science and Technology, Tongji University
Aravinthan D. T. Samuel: Center for Brain Science, Harvard University
Norbert Perrimon: Harvard Medical School

Nature, 2018, vol. 555, issue 7694, 103-106

Abstract: Stem cells of the Drosophila midgut sense mechanical signals in vivo through the stretch-activated ion channel Piezo, which is expressed on previously unidentified enteroendocrine precursor cells.

Date: 2018
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DOI: 10.1038/nature25744

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