Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Mark H. T. Stappers, Alexandra E. Clark, Vishukumar Aimanianda, Stefan Bidula, Delyth M. Reid, Patawee Asamaphan, Sarah E. Hardison, Ivy M. Dambuza, Isabel Valsecchi, Bernhard Kerscher, Anthony Plato, Carol A. Wallace, Raif Yuecel, Betty Hebecker, Maria da Glória Teixeira Sousa, Cristina Cunha, Yan Liu, Ten Feizi, Axel A. Brakhage, Kyung J. Kwon-Chung, Neil A. R. Gow, Matteo Zanda, Monica Piras, Chiara Zanato, Martin Jaeger, Mihai G. Netea, Frank L. van de Veerdonk, João F. Lacerda, António Campos, Agostinho Carvalho, Janet A. Willment, Jean-Paul Latgé and Gordon D. Brown ()
Additional contact information
Mark H. T. Stappers: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Alexandra E. Clark: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Vishukumar Aimanianda: Unité des Aspergillus, Institut Pasteur
Stefan Bidula: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Delyth M. Reid: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Patawee Asamaphan: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Sarah E. Hardison: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Ivy M. Dambuza: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Isabel Valsecchi: Unité des Aspergillus, Institut Pasteur
Bernhard Kerscher: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Anthony Plato: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Carol A. Wallace: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Raif Yuecel: Iain Fraser Cytometry Centre, Institute of Medical Sciences, University of Aberdeen
Betty Hebecker: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Maria da Glória Teixeira Sousa: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Cristina Cunha: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
Yan Liu: Glycosciences Laboratory, Imperial College London
Ten Feizi: Glycosciences Laboratory, Imperial College London
Axel A. Brakhage: Leibniz Institute for Natural Product Research and Infection Biology (HKI), Friedrich Schiller University
Kyung J. Kwon-Chung: Molecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
Neil A. R. Gow: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Matteo Zanda: Institute of Medical Sciences, University of Aberdeen
Monica Piras: Institute of Medical Sciences, University of Aberdeen
Chiara Zanato: Institute of Medical Sciences, University of Aberdeen
Martin Jaeger: Radboud University Medical Center
Mihai G. Netea: Radboud University Medical Center
Frank L. van de Veerdonk: Radboud University Medical Center
João F. Lacerda: Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Universidade de Lisboa
António Campos: Serviço de Transplantação de Medula Óssea (STMO), Instituto Português de Oncologia do Porto
Agostinho Carvalho: Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
Janet A. Willment: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences
Jean-Paul Latgé: Unité des Aspergillus, Institut Pasteur
Gordon D. Brown: Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences

Nature, 2018, vol. 555, issue 7696, 382-386

Abstract: The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.

Date: 2018
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DOI: 10.1038/nature25974

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