Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, Sebastian G. B. Furness, Peishen Zhao, Lachlan Clydesdale, Cassandra Koole, Tin T. Truong, David M. Thal, Saifei Lei, Mazdak Radjainia, Radostin Danev, Wolfgang Baumeister, Ming-Wei Wang, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton () and Denise Wootten ()
Additional contact information
Yi-Lynn Liang: Monash Institute of Pharmaceutical Sciences, Monash University
Maryam Khoshouei: Max Planck Institute of Biochemistry
Alisa Glukhova: Monash Institute of Pharmaceutical Sciences, Monash University
Sebastian G. B. Furness: Monash Institute of Pharmaceutical Sciences, Monash University
Peishen Zhao: Monash Institute of Pharmaceutical Sciences, Monash University
Lachlan Clydesdale: Monash Institute of Pharmaceutical Sciences, Monash University
Cassandra Koole: Monash Institute of Pharmaceutical Sciences, Monash University
Tin T. Truong: Monash Institute of Pharmaceutical Sciences, Monash University
David M. Thal: Monash Institute of Pharmaceutical Sciences, Monash University
Saifei Lei: University of Chinese Academy of Sciences
Mazdak Radjainia: Monash Institute of Pharmaceutical Sciences, Monash University
Radostin Danev: Max Planck Institute of Biochemistry
Wolfgang Baumeister: Max Planck Institute of Biochemistry
Ming-Wei Wang: University of Chinese Academy of Sciences
Laurence J. Miller: Monash Institute of Pharmaceutical Sciences, Monash University
Arthur Christopoulos: Monash Institute of Pharmaceutical Sciences, Monash University
Patrick M. Sexton: Monash Institute of Pharmaceutical Sciences, Monash University
Denise Wootten: Monash Institute of Pharmaceutical Sciences, Monash University

Nature, 2018, vol. 555, issue 7694, 121-125

Abstract: The structure of the glucagon-like peptide 1 receptor (GLP-1R) with its biased agonist exendin-P5 sheds light on both receptor activation and the mechanism of biased agonism.

Date: 2018
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DOI: 10.1038/nature25773

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