The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

Alessandro Bertero, Stephanie Brown, Pedro Madrigal, Anna Osnato, Daniel Ortmann, Loukia Yiangou, Juned Kadiwala, Nina C. Hubner, Igor Ruiz de los Mozos, Christoph Sadée, An-Sofie Lenaerts, Shota Nakanoh, Rodrigo Grandy, Edward Farnell, Jernej Ule, Hendrik G. Stunnenberg, Sasha Mendjan and Ludovic Vallier ()
Additional contact information
Alessandro Bertero: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Stephanie Brown: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Pedro Madrigal: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Anna Osnato: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Daniel Ortmann: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Loukia Yiangou: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Juned Kadiwala: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Nina C. Hubner: Radboud University
Igor Ruiz de los Mozos: University College London
Christoph Sadée: University College London
An-Sofie Lenaerts: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Shota Nakanoh: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Rodrigo Grandy: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Edward Farnell: University of Cambridge
Jernej Ule: University College London
Hendrik G. Stunnenberg: Radboud University
Sasha Mendjan: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
Ludovic Vallier: Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge

Nature, 2018, vol. 555, issue 7695, 256-259

Abstract: The SMAD2 and SMAD3 protein interactome links TGFβ signalling to diverse effectors including m6A methyltransferase, which has a role in regulating differentiation of human pluripotent stem cells.

Date: 2018
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DOI: 10.1038/nature25784

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