EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A. Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V. Pragathi Masamsetti, Sydney Roston, Elizabeth R. Lawlor, Jeffrey A. Toretsky, Kimberly Stegmaier, Stephen L. Lessnick, Yidong Chen and Alexander J. R. Bishop ()
Additional contact information
Aparna Gorthi: University of Texas Health at San Antonio
July Carolina Romero: University of Texas Health at San Antonio
Eva Loranc: Greehey Children’s Cancer Research Institute, University of Texas Health at San Antonio
Lin Cao: Greehey Children’s Cancer Research Institute, University of Texas Health at San Antonio
Liesl A. Lawrence: University of Texas Health at San Antonio
Elicia Goodale: Greehey Children’s Cancer Research Institute, University of Texas Health at San Antonio
Amanda Balboni Iniguez: Dana-Farber Cancer Institute and Boston Children’s Hospital, Harvard Medical School
Xavier Bernard: University of Texas Health at San Antonio
V. Pragathi Masamsetti: Greehey Children’s Cancer Research Institute, University of Texas Health at San Antonio
Sydney Roston: Georgetown University
Elizabeth R. Lawlor: University of Michigan
Jeffrey A. Toretsky: Georgetown University
Kimberly Stegmaier: Dana-Farber Cancer Institute and Boston Children’s Hospital, Harvard Medical School
Stephen L. Lessnick: Center for Childhood Cancer and Blood Diseases, Nationwide Children’s Hospital
Yidong Chen: Greehey Children’s Cancer Research Institute, University of Texas Health at San Antonio
Alexander J. R. Bishop: University of Texas Health at San Antonio

Nature, 2018, vol. 555, issue 7696, 387-391

Abstract: The EWS–FLI1 fusion protein, expressed in Ewing sarcoma, increases global transcription, causes accumulation of R loops and replication stress, and impairs BRCA1-mediated repair.

Date: 2018
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DOI: 10.1038/nature25748

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