Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

Shawn F. Sorrells, Mercedes F. Paredes, Arantxa Cebrian-Silla, Kadellyn Sandoval, Dashi Qi, Kevin W. Kelley, David James, Simone Mayer, Julia Chang, Kurtis I. Auguste, Edward F. Chang, Antonio J. Gutierrez, Arnold R. Kriegstein, Gary W. Mathern, Michael C. Oldham, Eric J. Huang, Jose Manuel Garcia-Verdugo (), Zhengang Yang () and Arturo Alvarez-Buylla ()
Additional contact information
Shawn F. Sorrells: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
Mercedes F. Paredes: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
Arantxa Cebrian-Silla: Laboratorio de Neurobiología Comparada, Instituto Cavanilles, Universidad de Valencia, CIBERNED
Kadellyn Sandoval: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
Dashi Qi: State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Zhongshan Hospital, Fudan University
Kevin W. Kelley: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
David James: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
Simone Mayer: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
Julia Chang: David Geffen School of Medicine, Intellectual Development and Disabilities Research Center, University of California Los Angeles, Los Angeles
Kurtis I. Auguste: University of California San Francisco, San Francisco
Edward F. Chang: University of California San Francisco, San Francisco
Antonio J. Gutierrez: Unidad de Cirugía de la Epilepsia, Hospital Universitario La Fe
Arnold R. Kriegstein: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
Gary W. Mathern: David Geffen School of Medicine, University of California Los Angeles, Los Angeles
Michael C. Oldham: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
Eric J. Huang: University of California San Francisco, San Francisco
Jose Manuel Garcia-Verdugo: Laboratorio de Neurobiología Comparada, Instituto Cavanilles, Universidad de Valencia, CIBERNED
Zhengang Yang: State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Zhongshan Hospital, Fudan University
Arturo Alvarez-Buylla: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco

Nature, 2018, vol. 555, issue 7696, 377-381

Abstract: Recruitment of young neurons to the hippocampus decreases rapidly during the first years of life, and neurogenesis does not continue, or is extremely rare, in the adult human brain.

Date: 2018
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DOI: 10.1038/nature25975

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