Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

Sheng Wang (), Tao Che, Anat Levit, Brian K. Shoichet, Daniel Wacker () and Bryan L. Roth ()
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Sheng Wang: University of North Carolina at Chapel Hill
Tao Che: University of North Carolina at Chapel Hill
Anat Levit: University of California San Francisco
Brian K. Shoichet: University of California San Francisco
Daniel Wacker: University of North Carolina at Chapel Hill
Bryan L. Roth: University of North Carolina at Chapel Hill

Nature, 2018, vol. 555, issue 7695, 269-273

Abstract: An X-ray structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone reveals an extended binding pocket and indicates structural features that could be used to design drugs that specifically target the D2 receptor.

Date: 2018
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DOI: 10.1038/nature25758

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