Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Peter W. S. Hill, Harry G. Leitch, Cristina E. Requena, Zhiyi Sun, Rachel Amouroux, Monica Roman-Trufero, Malgorzata Borkowska, Jolyon Terragni, Romualdas Vaisvila, Sarah Linnett, Hakan Bagci, Gopuraja Dharmalingham, Vanja Haberle, Boris Lenhard, Yu Zheng, Sriharsa Pradhan and Petra Hajkova ()
Additional contact information
Peter W. S. Hill: MRC London Institute of Medical Sciences (LMS)
Harry G. Leitch: MRC London Institute of Medical Sciences (LMS)
Cristina E. Requena: MRC London Institute of Medical Sciences (LMS)
Zhiyi Sun: New England Biolabs, Inc.
Rachel Amouroux: MRC London Institute of Medical Sciences (LMS)
Monica Roman-Trufero: MRC London Institute of Medical Sciences (LMS)
Malgorzata Borkowska: MRC London Institute of Medical Sciences (LMS)
Jolyon Terragni: New England Biolabs, Inc.
Romualdas Vaisvila: New England Biolabs, Inc.
Sarah Linnett: MRC London Institute of Medical Sciences (LMS)
Hakan Bagci: MRC London Institute of Medical Sciences (LMS)
Gopuraja Dharmalingham: MRC London Institute of Medical Sciences (LMS)
Vanja Haberle: MRC London Institute of Medical Sciences (LMS)
Boris Lenhard: MRC London Institute of Medical Sciences (LMS)
Yu Zheng: New England Biolabs, Inc.
Sriharsa Pradhan: New England Biolabs, Inc.
Petra Hajkova: MRC London Institute of Medical Sciences (LMS)

Nature, 2018, vol. 555, issue 7696, 392-396

Abstract: Gonadal germline epigenetic reprogramming involves an interplay between DNA methylation, the polycomb complex and Tet1 in both DNA methylation dependent and independent roles, to ensure the activation of a specific subset of genes critical for progression of gametogenesis.

Date: 2018
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DOI: 10.1038/nature25964

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