A new era of rationally designed antipsychotics

David R. Sibley () and Lei Shi ()

Nature, 2018, vol. 555, issue 7695, 170-172

Abstract: The ideal drugs for treating schizophrenia are postulated to selectively block the D2 dopamine receptor with optimum binding kinetics. The structure of D2 bound to an antipsychotic sheds light on how to design such drugs.

Keywords: Chemical biology; Drug discovery; Structural biology (search for similar items in EconPapers)
Date: 2018
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DOI: 10.1038/d41586-018-02328-z

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