The protein histidine phosphatase LHPP is a tumour suppressor

Sravanth K. Hindupur, Marco Colombi, Stephen R. Fuhs, Matthias S. Matter, Yakir Guri, Kevin Adam, Marion Cornu, Salvatore Piscuoglio, Charlotte K. Y. Ng, Charles Betz, Dritan Liko, Luca Quagliata, Suzette Moes, Paul Jenoe, Luigi M. Terracciano, Markus H. Heim, Tony Hunter and Michael N. Hall ()
Additional contact information
Sravanth K. Hindupur: Biozentrum, University of Basel
Marco Colombi: Biozentrum, University of Basel
Stephen R. Fuhs: Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies
Matthias S. Matter: Institute of Pathology, University Hospital Basel
Yakir Guri: Biozentrum, University of Basel
Kevin Adam: Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies
Marion Cornu: Biozentrum, University of Basel
Salvatore Piscuoglio: Institute of Pathology, University Hospital Basel
Charlotte K. Y. Ng: Institute of Pathology, University Hospital Basel
Charles Betz: Biozentrum, University of Basel
Dritan Liko: Biozentrum, University of Basel
Luca Quagliata: Institute of Pathology, University Hospital Basel
Suzette Moes: Biozentrum, University of Basel
Paul Jenoe: Biozentrum, University of Basel
Luigi M. Terracciano: Institute of Pathology, University Hospital Basel
Markus H. Heim: University Hospital Basel
Tony Hunter: Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies
Michael N. Hall: Biozentrum, University of Basel

Nature, 2018, vol. 555, issue 7698, 678-682

Abstract: Decreased expression of histidine phosphatase LHPP, a novel tumour suppressor, results in increased global histidine phosphorylation and hepatocellular carcinoma.

Date: 2018
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DOI: 10.1038/nature26140

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