Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours

Xiaotu Ma, Yu Liu, Yanling Liu, Ludmil B. Alexandrov, Michael N. Edmonson, Charles Gawad, Xin Zhou, Yongjin Li, Michael C. Rusch, John Easton, Robert Huether, Veronica Gonzalez-Pena, Mark R. Wilkinson, Leandro C. Hermida, Sean Davis, Edgar Sioson, Stanley Pounds, Xueyuan Cao, Rhonda E. Ries, Zhaoming Wang, Xiang Chen, Li Dong, Sharon J. Diskin, Malcolm A. Smith, Jaime M. Guidry Auvil, Paul S. Meltzer, Ching C. Lau, Elizabeth J. Perlman, John M. Maris, Soheil Meshinchi, Stephen P. Hunger, Daniela S. Gerhard and Jinghui Zhang ()
Additional contact information
Xiaotu Ma: Computational Biology, St Jude Children’s Research Hospital
Yu Liu: Computational Biology, St Jude Children’s Research Hospital
Yanling Liu: Computational Biology, St Jude Children’s Research Hospital
Ludmil B. Alexandrov: University of California, San Diego
Michael N. Edmonson: Computational Biology, St Jude Children’s Research Hospital
Charles Gawad: Computational Biology, St Jude Children’s Research Hospital
Xin Zhou: Computational Biology, St Jude Children’s Research Hospital
Yongjin Li: Computational Biology, St Jude Children’s Research Hospital
Michael C. Rusch: Computational Biology, St Jude Children’s Research Hospital
John Easton: Computational Biology, St Jude Children’s Research Hospital
Robert Huether: Independent Researcher
Veronica Gonzalez-Pena: Oncology, St Jude Children’s Research Hospital
Mark R. Wilkinson: Computational Biology, St Jude Children’s Research Hospital
Leandro C. Hermida: Office of Cancer Genomics, National Cancer Institute
Sean Davis: Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH
Edgar Sioson: Computational Biology, St Jude Children’s Research Hospital
Stanley Pounds: St Jude Children’s Research Hospital
Xueyuan Cao: St Jude Children’s Research Hospital
Rhonda E. Ries: Fred Hutchinson Cancer Research Center, Seattle
Zhaoming Wang: Computational Biology, St Jude Children’s Research Hospital
Xiang Chen: Computational Biology, St Jude Children’s Research Hospital
Li Dong: Computational Biology, St Jude Children’s Research Hospital
Sharon J. Diskin: Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania
Malcolm A. Smith: Cancer Therapy Evaluation Program, National Cancer Institute
Jaime M. Guidry Auvil: Office of Cancer Genomics, National Cancer Institute
Paul S. Meltzer: Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH
Ching C. Lau: Connecticut Children’s Medical Center
Elizabeth J. Perlman: Ann & Robert H. Lurie Children’s Hospital of Chicago, Robert H. Lurie Cancer Center, Northwestern University
John M. Maris: Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania
Soheil Meshinchi: Fred Hutchinson Cancer Research Center, Seattle
Stephen P. Hunger: Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania
Daniela S. Gerhard: Office of Cancer Genomics, National Cancer Institute
Jinghui Zhang: Computational Biology, St Jude Children’s Research Hospital

Nature, 2018, vol. 555, issue 7696, 371-376

Abstract: Analysis of the genomes, exomes and transcriptomes of 1,699 childhood cancers identifies 142 driver genes.

Date: 2018
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DOI: 10.1038/nature25795

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