Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

Devram S. Ghorpade, Lale Ozcan (), Ze Zheng, Sarah M. Nicoloro, Yuefei Shen, Emily Chen, Matthias Blüher, Michael P. Czech and Ira Tabas ()
Additional contact information
Devram S. Ghorpade: Columbia University Medical Center
Lale Ozcan: Columbia University Medical Center
Ze Zheng: Columbia University Medical Center
Sarah M. Nicoloro: Program in Molecular Medicine, University of Massachusetts Medical School
Yuefei Shen: Program in Molecular Medicine, University of Massachusetts Medical School
Emily Chen: Proteomics Shared Resource in the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center
Matthias Blüher: University of Leipzig
Michael P. Czech: Program in Molecular Medicine, University of Massachusetts Medical School
Ira Tabas: Columbia University Medical Center

Nature, 2018, vol. 555, issue 7698, 673-677

Abstract: Hepatocytes secrete DPP4, which promotes adipose tissue inflammation and insulin resistance in obese mice, suggesting a new specific target for treatment of metabolic disorders.

Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature26138 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:555:y:2018:i:7698:d:10.1038_nature26138

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature26138

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().