Insulin resistance in cavefish as an adaptation to a nutrient-limited environment

Misty R. Riddle, Ariel C. Aspiras, Karin Gaudenz, Robert Peuß, Jenny Y. Sung, Brian Martineau, Megan Peavey, Andrew C. Box, Julius A. Tabin, Suzanne McGaugh, Richard Borowsky, Clifford J. Tabin () and Nicolas Rohner ()
Additional contact information
Misty R. Riddle: Harvard Medical School
Ariel C. Aspiras: Harvard Medical School
Karin Gaudenz: Stowers Institute for Medical Research
Robert Peuß: Stowers Institute for Medical Research
Jenny Y. Sung: Stowers Institute for Medical Research
Brian Martineau: Harvard Medical School
Megan Peavey: Harvard Medical School
Andrew C. Box: Stowers Institute for Medical Research
Julius A. Tabin: Harvard Medical School
Suzanne McGaugh: College of Biomedical Sciences, University of Minnesota
Richard Borowsky: New York University
Clifford J. Tabin: Harvard Medical School
Nicolas Rohner: Stowers Institute for Medical Research

Nature, 2018, vol. 555, issue 7698, 647-651

Abstract: Cavefish populations of the Mexican tetra, Astyanax mexicanus, carry a mutation in the insulin receptor gene that renders them insulin- and starvation-resistant relative to surface populations of the same species.

Date: 2018
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DOI: 10.1038/nature26136

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