A TRP channel trio mediates acute noxious heat sensing

Ine Vandewauw, Katrien De Clercq, Marie Mulier, Katharina Held, Silvia Pinto, Nele Van Ranst, Andrei Segal, Thierry Voet, Rudi Vennekens, Katharina Zimmermann, Joris Vriens () and Thomas Voets ()
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Ine Vandewauw: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
Katrien De Clercq: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
Marie Mulier: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
Katharina Held: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
Silvia Pinto: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
Nele Van Ranst: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
Andrei Segal: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
Thierry Voet: Laboratory of Reproductive Genomics, University of Leuven
Rudi Vennekens: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
Katharina Zimmermann: University of Erlangen-Nürnberg
Joris Vriens: Laboratory of Experimental Gynecology and Obstetrics, University of Leuven
Thomas Voets: Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven

Nature, 2018, vol. 555, issue 7698, 662-666

Abstract: Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.

Date: 2018
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DOI: 10.1038/nature26137

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