Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

Keren Bahar Halpern, Rom Shenhav, Orit Matcovitch-Natan, Beáta Tóth, Doron Lemze, Matan Golan, Efi E. Massasa, Shaked Baydatch, Shanie Landen, Andreas E. Moor, Alexander Brandis, Amir Giladi, Avigail Stokar-Avihail, Eyal David, Ido Amit () and Shalev Itzkovitz ()
Additional contact information
Keren Bahar Halpern: Weizmann Institute of Science
Rom Shenhav: Weizmann Institute of Science
Orit Matcovitch-Natan: Weizmann Institute of Science
Beáta Tóth: Weizmann Institute of Science
Doron Lemze: Weizmann Institute of Science
Matan Golan: Weizmann Institute of Science
Efi E. Massasa: Weizmann Institute of Science
Shaked Baydatch: Weizmann Institute of Science
Shanie Landen: Weizmann Institute of Science
Andreas E. Moor: Weizmann Institute of Science
Alexander Brandis: Biological Services, Weizmann Institute of Science
Amir Giladi: Weizmann Institute of Science
Avigail Stokar-Avihail: Weizmann Institute of Science
Eyal David: Weizmann Institute of Science
Ido Amit: Weizmann Institute of Science
Shalev Itzkovitz: Weizmann Institute of Science

Nature, 2017, vol. 542, issue 7641, 352-356

Abstract: Single-molecule fluorescence in situ hybridization is performed to identify several landmark genes in the liver and their level of expression in single-cell RNA sequencing is used to spatially reconstruct the zonation of all liver genes.

Date: 2017
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DOI: 10.1038/nature21065

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