Editing and methylation at a single site by functionally interdependent activities

Mary Anne T. Rubio, Kirk W. Gaston, Katherine M. McKenney, Ian M. C. Fleming, Zdeněk Paris, Patrick A. Limbach and Juan D. Alfonzo ()
Additional contact information
Mary Anne T. Rubio: Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University
Kirk W. Gaston: Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University
Katherine M. McKenney: Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University
Ian M. C. Fleming: Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University
Zdeněk Paris: Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University
Patrick A. Limbach: Rieveschl Laboratories for Mass Spectrometry, University of Cincinnati
Juan D. Alfonzo: Ohio State Biochemistry Program and The Center for RNA Biology, The Ohio State University

Nature, 2017, vol. 542, issue 7642, 494-497

Abstract: The C-to-U deamination at position 32 of tRNAThr in Trypanosoma brucei requires two enzymatic activities and proceeds via formation of a 3-methylcytosine intermediate, supporting the notion of a coupled modification system.

Date: 2017
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DOI: 10.1038/nature21396

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