Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

Giannicola Genovese (), Alessandro Carugo, James Tepper, Frederick Scott Robinson, Liren Li, Maria Svelto, Luigi Nezi, Denise Corti, Rosalba Minelli, Piergiorgio Pettazzoni, Tony Gutschner, Chia-Chin Wu, Sahil Seth, Kadir Caner Akdemir, Elisabetta Leo, Samirkumar Amin, Marco Dal Molin, Haoqiang Ying, Lawrence N. Kwong, Simona Colla, Koichi Takahashi, Papia Ghosh, Virginia Giuliani, Florian Muller, Prasenjit Dey, Shan Jiang, Jill Garvey, Chang-Gong Liu, Jianhua Zhang, Timothy P. Heffernan, Carlo Toniatti, Jason B. Fleming, Michael G. Goggins, Laura D. Wood, Alessandro Sgambato, Abbas Agaimy, Anirban Maitra, Charles W. M. Roberts, Huamin Wang, Andrea Viale, Ronald A. DePinho, Giulio F. Draetta () and Lynda Chin
Additional contact information
Giannicola Genovese: The University of Texas MD Anderson Cancer Center
Alessandro Carugo: The University of Texas MD Anderson Cancer Center
James Tepper: The University of Texas MD Anderson Cancer Center
Frederick Scott Robinson: The University of Texas MD Anderson Cancer Center
Liren Li: The University of Texas MD Anderson Cancer Center
Maria Svelto: The University of Texas MD Anderson Cancer Center
Luigi Nezi: The University of Texas MD Anderson Cancer Center
Denise Corti: The University of Texas MD Anderson Cancer Center
Rosalba Minelli: The University of Texas MD Anderson Cancer Center
Piergiorgio Pettazzoni: The University of Texas MD Anderson Cancer Center
Tony Gutschner: The University of Texas MD Anderson Cancer Center
Chia-Chin Wu: The University of Texas MD Anderson Cancer Center
Sahil Seth: The University of Texas MD Anderson Cancer Center
Kadir Caner Akdemir: The University of Texas MD Anderson Cancer Center
Elisabetta Leo: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Samirkumar Amin: The University of Texas MD Anderson Cancer Center
Marco Dal Molin: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21287, USA
Haoqiang Ying: The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Lawrence N. Kwong: The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Simona Colla: The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Koichi Takahashi: The University of Texas MD Anderson Cancer Center
Papia Ghosh: Office of Technology Commercialization, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Virginia Giuliani: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Florian Muller: The University of Texas MD Anderson Cancer Center
Prasenjit Dey: The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Shan Jiang: The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Jill Garvey: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Chang-Gong Liu: The University of Texas MD Anderson Cancer Center
Jianhua Zhang: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Timothy P. Heffernan: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Carlo Toniatti: ORBIT Platform, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Jason B. Fleming: The University of Texas MD Anderson Cancer Center
Michael G. Goggins: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21287, USA
Laura D. Wood: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland 21287, USA
Alessandro Sgambato: Istituto di Patologia Generale, Universitá Cattolica del Sacro Cuore, Rome 00168, Italy
Abbas Agaimy: Friedrich Alexander University Erlangen-Nuremberg, University Hospital
Anirban Maitra: The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Charles W. M. Roberts: St Jude Children’s Research Hospital, Memphis, Tennessee 77027, USA
Huamin Wang: The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Andrea Viale: The University of Texas MD Anderson Cancer Center
Ronald A. DePinho: The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Giulio F. Draetta: The University of Texas MD Anderson Cancer Center
Lynda Chin: The University of Texas MD Anderson Cancer Center

Nature, 2017, vol. 542, issue 7641, 362-366

Abstract: Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly aggressive Kras-independent pancreatic cancer cells to develop.

Date: 2017
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DOI: 10.1038/nature21064

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