m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

Boxuan Simen Zhao, Xiao Wang, Alana V. Beadell, Zhike Lu, Hailing Shi, Adam Kuuspalu, Robert K. Ho and Chuan He ()
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Boxuan Simen Zhao: The University of Chicago
Xiao Wang: The University of Chicago
Alana V. Beadell: The University of Chicago
Zhike Lu: The University of Chicago
Hailing Shi: The University of Chicago
Adam Kuuspalu: The University of Chicago
Robert K. Ho: The University of Chicago
Chuan He: The University of Chicago

Nature, 2017, vol. 542, issue 7642, 475-478

Abstract: The N6-methyladenosine (m6A) modification facilitates maternally driven clearance of zebrafish maternal mRNAs through the m6A-binding protein Ythdf2, ensuring proper and timely embryonic development.

Date: 2017
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DOI: 10.1038/nature21355

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