α2δ expression sets presynaptic calcium channel abundance and release probability

Michael B. Hoppa, Beatrice Lana, Wojciech Margas, Annette C. Dolphin and Timothy A. Ryan ()
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Michael B. Hoppa: Weill Cornell Medical College
Beatrice Lana: Physiology and Pharmacology, Laboratory of Cellular and Molecular Neuroscience, University College London, London WC1E6BT, UK
Wojciech Margas: Physiology and Pharmacology, Laboratory of Cellular and Molecular Neuroscience, University College London, London WC1E6BT, UK
Annette C. Dolphin: Physiology and Pharmacology, Laboratory of Cellular and Molecular Neuroscience, University College London, London WC1E6BT, UK
Timothy A. Ryan: Weill Cornell Medical College

Nature, 2012, vol. 486, issue 7401, 122-125

Abstract: The voltage-gated calcium channel protein subunit α2δ is shown to control both the abundance of voltage-gated calcium channels and their coupling to the vesicular release of neurotransmitters into the synapse; because the α2δ family is a known target of potent analgesics, this study offers a new link between basic synaptic physiology and pain research in the clinic.

Date: 2012
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DOI: 10.1038/nature11033

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