An oxygen-regulated switch in the protein synthesis machinery

James Uniacke, Chet E. Holterman, Gabriel Lachance, Aleksandra Franovic, Mathieu D. Jacob, Marc R. Fabian, Josianne Payette, Martin Holcik, Arnim Pause and Stephen Lee ()
Additional contact information
James Uniacke: Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Chet E. Holterman: Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Gabriel Lachance: Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Aleksandra Franovic: Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Mathieu D. Jacob: Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Marc R. Fabian: Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
Josianne Payette: Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
Martin Holcik: Apoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada K1H 8L1
Arnim Pause: Goodman Cancer Research Center, McGill University, Montreal, Quebec, Canada H3G 1Y6
Stephen Lee: Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5

Nature, 2012, vol. 486, issue 7401, 126-129

Abstract: Hypoxia activates a translation initiation pathway that escapes global inhibition of protein synthesis.

Date: 2012
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DOI: 10.1038/nature11055

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