The diversity-generating benefits of a prokaryotic adaptive immune system

Stineke van Houte (), Alice K. E. Ekroth, Jenny M. Broniewski, Hélène Chabas, Ben Ashby, Joseph Bondy-Denomy, Sylvain Gandon, Mike Boots, Steve Paterson, Angus Buckling () and Edze R. Westra ()
Additional contact information
Stineke van Houte: ESI and CEC, Biosciences, University of Exeter, Cornwall Campus
Alice K. E. Ekroth: ESI and CEC, Biosciences, University of Exeter, Cornwall Campus
Jenny M. Broniewski: ESI and CEC, Biosciences, University of Exeter, Cornwall Campus
Hélène Chabas: ESI and CEC, Biosciences, University of Exeter, Cornwall Campus
Ben Ashby: University of California
Joseph Bondy-Denomy: University of California, San Francisco, San Francisco, California 94158, USA
Sylvain Gandon: CEFE UMR 5175, CNRS-Université de Montpellier, Université Paul-Valéry Montpellier, EPHE, 1919
Mike Boots: University of California
Steve Paterson: Institute of Integrative Biology, University of Liverpool
Angus Buckling: ESI and CEC, Biosciences, University of Exeter, Cornwall Campus
Edze R. Westra: ESI and CEC, Biosciences, University of Exeter, Cornwall Campus

Nature, 2016, vol. 532, issue 7599, 385-388

Abstract: Population-level spacer diversity is a key fitness determinant of CRISPR-Cas adaptive immune systems because it limits the emergence of escape virus.

Date: 2016
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DOI: 10.1038/nature17436

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