Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

Ryu Okumura, Takashi Kurakawa, Takashi Nakano, Hisako Kayama, Makoto Kinoshita, Daisuke Motooka, Kazuyoshi Gotoh, Taishi Kimura, Naganori Kamiyama, Takashi Kusu, Yoshiyasu Ueda, Hong Wu, Hideki Iijima, Soumik Barman, Hideki Osawa, Hiroshi Matsuno, Junichi Nishimura, Yusuke Ohba, Shota Nakamura, Tetsuya Iida, Masahiro Yamamoto, Eiji Umemoto, Koichi Sano and Kiyoshi Takeda ()
Additional contact information
Ryu Okumura: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Takashi Kurakawa: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Takashi Nakano: Osaka Medical College
Hisako Kayama: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Makoto Kinoshita: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Daisuke Motooka: Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
Kazuyoshi Gotoh: Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
Taishi Kimura: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Naganori Kamiyama: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Takashi Kusu: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Yoshiyasu Ueda: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Hong Wu: Osaka Medical College
Hideki Iijima: Graduate School of Medicine, Osaka University
Soumik Barman: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Hideki Osawa: Graduate School of Medicine, Osaka University
Hiroshi Matsuno: Graduate School of Medicine, Osaka University
Junichi Nishimura: Graduate School of Medicine, Osaka University
Yusuke Ohba: Hokkaido University Graduate School of Medicine
Shota Nakamura: Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
Tetsuya Iida: Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
Masahiro Yamamoto: Laboratory of Immunoparasitology, Research Institute for Microbial Diseases, WPI Immunology Frontier Research Center, Osaka University
Eiji Umemoto: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University
Koichi Sano: Osaka Medical College
Kiyoshi Takeda: Laboratory of Immune Regulation, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka University

Nature, 2016, vol. 532, issue 7597, 117-121

Abstract: Lypd8 protein derived from intestinal epithelial cells binds to flagellated bacteria to reduce their motility, which limits the entry of Gram-negative bacteria into the inner colonic mucus and prevents invasion of colonic epithelia.

Date: 2016
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DOI: 10.1038/nature17406

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