Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Lei Jiang, Alexander A. Shestov, Pamela Swain, Chendong Yang, Seth J. Parker, Qiong A. Wang, Lance S. Terada, Nicholas D. Adams, Michael T. McCabe, Beth Pietrak, Stan Schmidt, Christian M. Metallo, Brian P. Dranka, Benjamin Schwartz and Ralph J. DeBerardinis ()
Additional contact information
Lei Jiang: Children’s Medical Center Research Institute, UT Southwestern Medical Center
Alexander A. Shestov: University of Pennsylvania School of Medicine
Pamela Swain: Seahorse Bioscience
Chendong Yang: Children’s Medical Center Research Institute, UT Southwestern Medical Center
Seth J. Parker: University of California
Qiong A. Wang: Touchstone Diabetes Center, UT Southwestern Medical Center
Lance S. Terada: UT Southwestern Medical Center
Nicholas D. Adams: GlaxoSmithKline
Michael T. McCabe: GlaxoSmithKline
Beth Pietrak: GlaxoSmithKline
Stan Schmidt: GlaxoSmithKline
Christian M. Metallo: University of California
Brian P. Dranka: Seahorse Bioscience
Benjamin Schwartz: GlaxoSmithKline
Ralph J. DeBerardinis: Children’s Medical Center Research Institute, UT Southwestern Medical Center

Nature, 2016, vol. 532, issue 7598, 255-258

Abstract: Malignant cells are able to survive and grow in detached conditions, despite the associated increase in reactive oxygen species; here a novel metabolic pathway used by cancer cells as they adapt to anchorage-independent growth is described.

Date: 2016
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DOI: 10.1038/nature17393

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