Structural basis of cohesin cleavage by separase

Zhonghui Lin, Xuelian Luo and Hongtao Yu ()
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Zhonghui Lin: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center
Xuelian Luo: University of Texas Southwestern Medical Center
Hongtao Yu: Howard Hughes Medical Institute, University of Texas Southwestern Medical Center

Nature, 2016, vol. 532, issue 7597, 131-134

Abstract: The crystal structures of the protease domain of separase are reported, showing how separase recognizes cohesin, and how phosphorylation of the cleavage site enhances separase activity.

Date: 2016
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DOI: 10.1038/nature17402

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