The crystal structure of Cpf1 in complex with CRISPR RNA

Dong De, Kuan Ren, Xiaolin Qiu, Jianlin Zheng, Minghui Guo, Xiaoyu Guan, Hongnan Liu, Ningning Li, Bailing Zhang, Daijun Yang, Chuang Ma, Shuo Wang, Dan Wu, Yunfeng Ma, Shilong Fan, Jiawei Wang, Ning Gao and Zhiwei Huang ()
Additional contact information
Dong De: School of Life Science and Technology, Harbin Institute of Technology
Kuan Ren: School of Life Science and Technology, Harbin Institute of Technology
Xiaolin Qiu: School of Life Science and Technology, Harbin Institute of Technology
Jianlin Zheng: School of Life Science and Technology, Harbin Institute of Technology
Minghui Guo: School of Life Science and Technology, Harbin Institute of Technology
Xiaoyu Guan: School of Life Science and Technology, Harbin Institute of Technology
Hongnan Liu: School of Life Science and Technology, Harbin Institute of Technology
Ningning Li: Ministry of Education Key Laboratory of Protein Sciences, Center for Structural Biology, School of Life Sciences, Tsinghua University
Bailing Zhang: School of Life Science and Technology, Harbin Institute of Technology
Daijun Yang: School of Life Science and Technology, Harbin Institute of Technology
Chuang Ma: School of Life Science and Technology, Harbin Institute of Technology
Shuo Wang: School of Life Science and Technology, Harbin Institute of Technology
Dan Wu: School of Life Science and Technology, Harbin Institute of Technology
Yunfeng Ma: School of Life Science and Technology, Harbin Institute of Technology
Shilong Fan: Ministry of Education Key Laboratory of Protein Sciences, Center for Structural Biology, School of Life Sciences, Tsinghua University
Jiawei Wang: Ministry of Education Key Laboratory of Protein Sciences, Center for Structural Biology, School of Life Sciences, Tsinghua University
Ning Gao: Ministry of Education Key Laboratory of Protein Sciences, Center for Structural Biology, School of Life Sciences, Tsinghua University
Zhiwei Huang: School of Life Science and Technology, Harbin Institute of Technology

Nature, 2016, vol. 532, issue 7600, 522-526

Abstract: The crystal structure of monomeric Lachnospiraceae bacterium Cpf1 protein bound to CRISPR RNA is presented, establishing a framework for engineering LbCpf1 to improve its efficiency and specificity for genome editing.

Date: 2016
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DOI: 10.1038/nature17944

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