Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation

Dimitre R. Simeonov, Benjamin G. Gowen, Mandy Boontanrart, Theodore L. Roth, John D. Gagnon, Maxwell R. Mumbach, Ansuman T. Satpathy, Youjin Lee, Nicolas L. Bray, Alice Y. Chan, Dmytro S. Lituiev, Michelle L. Nguyen, Rachel E. Gate, Meena Subramaniam, Zhongmei Li, Jonathan M. Woo, Therese Mitros, Graham J. Ray, Gemma L. Curie, Nicki Naddaf, Julia S. Chu, Hong Ma, Eric Boyer, Frederic Gool, Hailiang Huang, Ruize Liu, Victoria R. Tobin, Kathrin Schumann, Mark J. Daly, Kyle K. Farh, K. Mark Ansel, Chun J. Ye, William J. Greenleaf, Mark S. Anderson, Jeffrey A. Bluestone, Howard Y. Chang, Jacob E. Corn () and Alexander Marson ()
Additional contact information
Dimitre R. Simeonov: University of California
Benjamin G. Gowen: University of California
Mandy Boontanrart: University of California
Theodore L. Roth: University of California
John D. Gagnon: University of California
Maxwell R. Mumbach: Stanford University School of Medicine
Ansuman T. Satpathy: Stanford University School of Medicine
Youjin Lee: University of California
Nicolas L. Bray: University of California
Alice Y. Chan: Diabetes Center, University of California
Dmytro S. Lituiev: University of California
Michelle L. Nguyen: University of California
Rachel E. Gate: University of California
Meena Subramaniam: University of California
Zhongmei Li: University of California
Jonathan M. Woo: University of California
Therese Mitros: University of California
Graham J. Ray: University of California
Gemma L. Curie: University of California
Nicki Naddaf: University of California
Julia S. Chu: University of California
Hong Ma: University of California
Eric Boyer: Diabetes Center, University of California
Frederic Gool: Diabetes Center, University of California
Hailiang Huang: Broad Institute of MIT and Harvard
Ruize Liu: Broad Institute of MIT and Harvard
Victoria R. Tobin: University of California
Kathrin Schumann: University of California
Mark J. Daly: Broad Institute of MIT and Harvard
Kyle K. Farh: Illumina Inc., 5200 Illumina Way
K. Mark Ansel: University of California
Chun J. Ye: University of California
William J. Greenleaf: Stanford University School of Medicine
Mark S. Anderson: Diabetes Center, University of California
Jeffrey A. Bluestone: Diabetes Center, University of California
Howard Y. Chang: Stanford University School of Medicine
Jacob E. Corn: University of California
Alexander Marson: University of California

Nature, 2018, vol. 559, issue 7715, E13-E13

Abstract: In this Letter, analysis of steady-state regulatory T (Treg) cell percentages from Il2ra enhancer deletion (EDEL) and wild-type (WT) mice revealed no differences between them (Extended Data Fig. 9d). This analysis included two mice whose genotypes were incorrectly assigned. Even after correction of the genotypes, no significant differences in Treg cell percentages were seen when data across experimental cohorts were averaged (as was done in Extended Data Fig. 9d). However, if we normalize the corrected data to account for variation among experimental cohorts, a subtle decrease in EDEL Treg cell percentages is revealed and, using the corrected and normalized data, we have redrawn Extended Data Fig. 9d in Supplementary Fig. 1. The Supplementary Information to this Amendment contains the corrected and reanalysed Extended Data Fig. 9d. The sentence “This enhancer deletion (EDEL) strain also had no obvious T cell phenotypes at steady state (Extended Data Fig. 9).” should read: “This enhancer deletion (EDEL) strain had a small decrease in the percentage of Treg cells (Extended Data Fig. 9).”. This error does not affect any of the main figures in the Letter or the data from mice with the human autoimmune-associated single nucleotide polymorphism (SNP) knocked in or with a 12-base-pair deletion at the site (12DEL). In addition, we stated in the Methods that we observed consistent immunophenotypes of EDEL mice across three founders, but in fact, we observed consistent phenotypes in mice from two founders. This does not change any of our conclusions and the original Letter has not been corrected.

Date: 2018
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DOI: 10.1038/s41586-018-0227-7

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