Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells

Marina Bershteyn, Yohei Hayashi, Guillaume Desachy, Edward C. Hsiao, Salma Sami, Kathryn M. Tsang, Lauren A. Weiss, Arnold R. Kriegstein, Shinya Yamanaka () and Anthony Wynshaw-Boris ()
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Marina Bershteyn: University of California, San Francisco
Yohei Hayashi: Gladstone Institute of Cardiovascular Disease, San Francisco
Guillaume Desachy: Institute for Human Genetics, University of California, San Francisco
Edward C. Hsiao: University of California, San Francisco
Salma Sami: Gladstone Institute of Cardiovascular Disease, San Francisco
Kathryn M. Tsang: Institute for Human Genetics, University of California, San Francisco
Lauren A. Weiss: Institute for Human Genetics, University of California, San Francisco
Arnold R. Kriegstein: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco
Shinya Yamanaka: Gladstone Institute of Cardiovascular Disease, San Francisco
Anthony Wynshaw-Boris: University of California, San Francisco

Nature, 2014, vol. 507, issue 7490, 99-103

Abstract: Generation of human induced pluripotent stem cells from patient fibroblasts containing ring chromosomes with large deletions reveals that reprogrammed cells lose the abnormal chromosome and duplicate the wild-type homologue through compensatory uniparental disomy, suggesting that cellular reprogramming may hold potential for ‘chromosome therapy’.

Date: 2014
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DOI: 10.1038/nature12923

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