IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Ping Shen, Toralf Roch, Vicky Lampropoulou, Richard A. O’Connor, Ulrik Stervbo, Ellen Hilgenberg, Stefanie Ries, Dang Van Duc, Yarúa Jaimes, Capucine Daridon, Rui Li, Luc Jouneau, Pierre Boudinot, Siska Wilantri, Imme Sakwa, Yusei Miyazaki, Melanie D. Leech, Rhoanne C. McPherson, Stefan Wirtz, Markus Neurath, Kai Hoehlig, Edgar Meinl, Andreas Grützkau, Joachim R. Grün, Katharina Horn, Anja A. Kühl, Thomas Dörner, Amit Bar-Or, Stefan H. E. Kaufmann, Stephen M. Anderton and Simon Fillatreau ()
Additional contact information
Ping Shen: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Toralf Roch: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Vicky Lampropoulou: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Richard A. O’Connor: University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK
Ulrik Stervbo: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Ellen Hilgenberg: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Stefanie Ries: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Dang Van Duc: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Yarúa Jaimes: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Capucine Daridon: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Rui Li: Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada
Luc Jouneau: Virologie et Immunologie Moléculaires, INRA, 78352 Jouy-en-Josas, France
Pierre Boudinot: Virologie et Immunologie Moléculaires, INRA, 78352 Jouy-en-Josas, France
Siska Wilantri: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Imme Sakwa: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Yusei Miyazaki: Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada
Melanie D. Leech: University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK
Rhoanne C. McPherson: University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK
Stefan Wirtz: Medical Clinic 1, Kussmaul Campus for Medical Research, University of Erlangen-Nürnberg, 91054 Erlangen, Germany
Markus Neurath: Medical Clinic 1, Kussmaul Campus for Medical Research, University of Erlangen-Nürnberg, 91054 Erlangen, Germany
Kai Hoehlig: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Edgar Meinl: Institut für Klinische Neuroimmunologie Klinikum der Ludwig-Maximilians-Universität München, 81377 München, Germany
Andreas Grützkau: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Joachim R. Grün: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Katharina Horn: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Anja A. Kühl: Immunpathologie, Research Center ImmunoSciences, 12203 Berlin, Germany
Thomas Dörner: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany
Amit Bar-Or: Neuroimmunology Unit, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A2B4, Canada
Stefan H. E. Kaufmann: Max Planck Institute of Infection Biology, Charitéplatz 1, 10117 Berlin, Germany
Stephen M. Anderton: University of Edinburgh, Centre for Inflammation Research and Centre for Multiple Sclerosis Research, Queen’s Medical Research Institute, Edinburgh EH16 4TJ, UK
Simon Fillatreau: Deutsches Rheuma-Forschungszentrum, a Leibniz Institute, Charitéplatz 1, 10117 Berlin, Germany

Nature, 2014, vol. 507, issue 7492, 366-370

Abstract: B cells can secrete IL-35 upon activation, and subsequently contribute negatively to the regulation of immunity, such as T-cell-mediated autoimmunity or anti-microbial immunity, and a characterization of these cells raises new questions about possible independent roles for IL-10- and IL-35-expressing plasma cells as regulatory cells.

Date: 2014
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DOI: 10.1038/nature12979

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