Citrullination regulates pluripotency and histone H1 binding to chromatin

Maria A. Christophorou, Gonçalo Castelo-Branco, Richard P. Halley-Stott, Clara Slade Oliveira, Remco Loos, Aliaksandra Radzisheuskaya, Kerri A. Mowen, Paul Bertone, José C. R. Silva, Magdalena Zernicka-Goetz, Michael L. Nielsen, John B. Gurdon and Tony Kouzarides ()
Additional contact information
Maria A. Christophorou: The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Gonçalo Castelo-Branco: The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Richard P. Halley-Stott: The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Clara Slade Oliveira: The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Remco Loos: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
Aliaksandra Radzisheuskaya: Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Kerri A. Mowen: The Scripps Research Institute
Paul Bertone: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
José C. R. Silva: Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Magdalena Zernicka-Goetz: The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Michael L. Nielsen: The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health Sciences, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark
John B. Gurdon: The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
Tony Kouzarides: The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK

Nature, 2014, vol. 507, issue 7490, 104-108

Abstract: This study shows that PADI4-mediated citrullination occurs during pluripotency and that citrullination of H1 results in loosening of chromatin compaction; furthermore, citrullination is shown to be important for the activation of stem-cell genes, for iPS cell reprogramming and to maintain pluripotent cells in the early mouse embryo.

Date: 2014
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DOI: 10.1038/nature12942

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