Structure-based programming of lymph-node targeting in molecular vaccines

Haipeng Liu, Kelly D. Moynihan, Yiran Zheng, Gregory L. Szeto, Adrienne V. Li, Bonnie Huang, Debra S. Van Egeren, Clara Park and Darrell J. Irvine ()
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Haipeng Liu: Massachusetts Institute of Technology
Kelly D. Moynihan: Massachusetts Institute of Technology
Yiran Zheng: Massachusetts Institute of Technology
Gregory L. Szeto: Massachusetts Institute of Technology
Adrienne V. Li: Massachusetts Institute of Technology
Bonnie Huang: Massachusetts Institute of Technology
Debra S. Van Egeren: Massachusetts Institute of Technology
Clara Park: Massachusetts Institute of Technology
Darrell J. Irvine: Massachusetts Institute of Technology

Nature, 2014, vol. 507, issue 7493, 519-522

Abstract: An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes.

Date: 2014
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DOI: 10.1038/nature12978

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