Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

Kaushik Choudhuri, Jaime Llodrá, Eric W. Roth, Jones Tsai, Susana Gordo, Kai W. Wucherpfennig, Lance C. Kam, David L. Stokes () and Michael L. Dustin ()
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Kaushik Choudhuri: Program in Molecular Pathogenesis, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, New York 10016, USA
Jaime Llodrá: Program in Structural Biology, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, New York 10016, USA
Eric W. Roth: Northwestern University Atomic and Nanoscale Characterization Experimental Center, Northwestern University, 2220 Campus Drive
Jones Tsai: Columbia University, 500 W 120th Street, New York, New York 10027, USA
Susana Gordo: Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
Kai W. Wucherpfennig: Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
Lance C. Kam: Columbia University, 500 W 120th Street, New York, New York 10027, USA
David L. Stokes: Program in Structural Biology, Helen L. and Martin S. Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, 540 First Avenue, New York, New York 10016, USA
Michael L. Dustin: New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA

Nature, 2014, vol. 507, issue 7490, 118-123

Abstract: Here it is shown that T-cell receptors accumulate at the immunological synapse after stimulation with cognate antigen and are released in extracellular microvesicles by an ESCRT-dependent mechanism, the microvesicles deliver transcellular signals from CD4 T cells to antigen-presenting B cells and can induce B-cell signalling.

Date: 2014
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DOI: 10.1038/nature12951

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