Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

Tobias Bald, Thomas Quast, Jennifer Landsberg, Meri Rogava, Nicole Glodde, Dorys Lopez-Ramos, Judith Kohlmeyer, Stefanie Riesenberg, Debby van den Boorn-Konijnenberg, Cornelia Hömig-Hölzel, Raphael Reuten, Benjamin Schadow, Heike Weighardt, Daniela Wenzel, Iris Helfrich, Dirk Schadendorf, Wilhelm Bloch, Marco E. Bianchi, Claire Lugassy, Raymond L. Barnhill, Manuel Koch, Bernd K. Fleischmann, Irmgard Förster, Wolfgang Kastenmüller, Waldemar Kolanus, Michael Hölzel (), Evelyn Gaffal () and Thomas Tüting ()
Additional contact information
Tobias Bald: Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany
Thomas Quast: Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany
Jennifer Landsberg: Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany
Meri Rogava: Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany
Nicole Glodde: Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany
Dorys Lopez-Ramos: Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany
Judith Kohlmeyer: Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany
Stefanie Riesenberg: Unit for RNA Biology, University of Bonn, 53105 Bonn, Germany
Debby van den Boorn-Konijnenberg: Unit for RNA Biology, University of Bonn, 53105 Bonn, Germany
Cornelia Hömig-Hölzel: Unit for RNA Biology, University of Bonn, 53105 Bonn, Germany
Raphael Reuten: Institute for Dental Research and Oral Musculoskeletal Biology, Center for Biochemistry, Medical Faculty, University of Cologne, D-50931 Cologne, Germany
Benjamin Schadow: Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany
Heike Weighardt: Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany
Daniela Wenzel: Institute for Physiology I, Life & Brain Center, University of Bonn, 53105 Bonn, Germany
Iris Helfrich: University Hospital Essen, 45122 Essen, Germany
Dirk Schadendorf: University Hospital Essen, 45122 Essen, Germany
Wilhelm Bloch: Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, 50933 Cologne, Germany
Marco E. Bianchi: San Raffaele University and Scientific Institute, 20132 Milan, Italy
Claire Lugassy: Jonsson Comprehensive Cancer Center, University of California Los Angeles (UCLA) Medical Center
Raymond L. Barnhill: Jonsson Comprehensive Cancer Center, University of California Los Angeles (UCLA) Medical Center
Manuel Koch: Institute for Dental Research and Oral Musculoskeletal Biology, Center for Biochemistry, Medical Faculty, University of Cologne, D-50931 Cologne, Germany
Bernd K. Fleischmann: Institute for Physiology I, Life & Brain Center, University of Bonn, 53105 Bonn, Germany
Irmgard Förster: Immunology and Environment, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany
Wolfgang Kastenmüller: Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, 53105 Bonn, Germany
Waldemar Kolanus: Molecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany
Michael Hölzel: Unit for RNA Biology, University of Bonn, 53105 Bonn, Germany
Evelyn Gaffal: Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany
Thomas Tüting: Laboratory of Experimental Dermatology, University of Bonn, 53115 Bonn, Germany

Nature, 2014, vol. 507, issue 7490, 109-113

Abstract: Mouse experiments show that ultraviolet radiation can promote tumour metastasis in melanoma by enhancing the expansion of tumour cells on blood vessel surfaces in a process linked to inflammation and requiring neutrophils and the proteins HMGB1 and TLR4.

Date: 2014
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DOI: 10.1038/nature13111

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