L-Myc expression by dendritic cells is required for optimal T-cell priming

Wumesh Kc, Ansuman T. Satpathy, Aaron S. Rapaport, Carlos G. Briseño, Xiaodi Wu, Jörn C. Albring, Emilie V. Russler-Germain, Nicole M. Kretzer, Vivek Durai, Stephen P. Persaud, Brian T. Edelson, Jakob Loschko, Marina Cella, Paul M. Allen, Michel C. Nussenzweig, Marco Colonna, Barry P. Sleckman, Theresa L. Murphy and Kenneth M. Murphy ()
Additional contact information
Wumesh Kc: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Ansuman T. Satpathy: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Aaron S. Rapaport: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Carlos G. Briseño: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Xiaodi Wu: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Jörn C. Albring: Hematology and Oncology, University of Muenster, 48149 Muenster, Germany
Emilie V. Russler-Germain: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Nicole M. Kretzer: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Vivek Durai: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Stephen P. Persaud: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Brian T. Edelson: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Jakob Loschko: Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University
Marina Cella: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Paul M. Allen: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Michel C. Nussenzweig: Laboratory of Molecular Immunology, Howard Hughes Medical Institute, The Rockefeller University
Marco Colonna: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Barry P. Sleckman: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Theresa L. Murphy: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA
Kenneth M. Murphy: Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, Missouri 63110, USA

Nature, 2014, vol. 507, issue 7491, 243-247

Abstract: L-Myc, a paralogue of the proto-oncogene c-Myc, is shown to regulate dendritic cell homeostasis and functionality; unlike c-Myc, L-Myc is not repressed by interferons and its expression allows for optimal dendritic cell proliferation and T-cell priming in the presence of inflammation.

Date: 2014
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DOI: 10.1038/nature12967

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