CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
Marian L. Burr (),
Christina E. Sparbier,
Yih-Chih Chan,
James C. Williamson,
Katherine Woods,
Paul A. Beavis,
Enid Y. N. Lam,
Melissa A. Henderson,
Charles C. Bell,
Sabine Stolzenburg,
Omer Gilan,
Stuart Bloor,
Tahereh Noori,
David W. Morgens,
Michael C. Bassik,
Paul J. Neeson,
Andreas Behren,
Phillip K. Darcy,
Sarah-Jane Dawson,
Ilia Voskoboinik,
Joseph A. Trapani,
Jonathan Cebon,
Paul J. Lehner () and
Mark A. Dawson ()
Additional contact information
Marian L. Burr: Peter MacCallum Cancer Centre
Christina E. Sparbier: Peter MacCallum Cancer Centre
Yih-Chih Chan: Peter MacCallum Cancer Centre
James C. Williamson: Cambridge Institute for Medical Research, Cambridge Biomedical Campus
Katherine Woods: School of Cancer Medicine, La Trobe University
Paul A. Beavis: Peter MacCallum Cancer Centre
Enid Y. N. Lam: Peter MacCallum Cancer Centre
Melissa A. Henderson: Peter MacCallum Cancer Centre
Charles C. Bell: Peter MacCallum Cancer Centre
Sabine Stolzenburg: Peter MacCallum Cancer Centre
Omer Gilan: Peter MacCallum Cancer Centre
Stuart Bloor: Cambridge Institute for Medical Research, Cambridge Biomedical Campus
Tahereh Noori: Peter MacCallum Cancer Centre
David W. Morgens: Stanford University
Michael C. Bassik: Stanford University
Paul J. Neeson: Peter MacCallum Cancer Centre
Andreas Behren: School of Cancer Medicine, La Trobe University
Phillip K. Darcy: Peter MacCallum Cancer Centre
Sarah-Jane Dawson: Peter MacCallum Cancer Centre
Ilia Voskoboinik: Peter MacCallum Cancer Centre
Joseph A. Trapani: Peter MacCallum Cancer Centre
Jonathan Cebon: School of Cancer Medicine, La Trobe University
Paul J. Lehner: Cambridge Institute for Medical Research, Cambridge Biomedical Campus
Mark A. Dawson: Peter MacCallum Cancer Centre
Nature, 2017, vol. 549, issue 7670, 101-105
Abstract:
CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.
Date: 2017
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DOI: 10.1038/nature23643
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