Competing memories of mitogen and p53 signalling control cell-cycle entry

Hee Won Yang (), Mingyu Chung, Takamasa Kudo and Tobias Meyer ()
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Hee Won Yang: Stanford University School of Medicine, Stanford
Mingyu Chung: Stanford University School of Medicine, Stanford
Takamasa Kudo: Stanford University School of Medicine, Stanford
Tobias Meyer: Stanford University School of Medicine, Stanford

Nature, 2017, vol. 549, issue 7672, 404-408

Abstract: Mother cells transmit mitogen-induced CCND1 mRNA and DNA damage-induced p53 protein to newly born daughter cells, where synthesized cyclin D1 and the p53-regulated CDK inhibitor p21 directly compete to decide between proliferation and quiescence.

Date: 2017
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DOI: 10.1038/nature23880

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