Parental influence on human germline de novo mutations in 1,548 trios from Iceland

Hákon Jónsson, Patrick Sulem, Birte Kehr, Snaedis Kristmundsdottir, Florian Zink, Eirikur Hjartarson, Marteinn T. Hardarson, Kristjan E. Hjorleifsson, Hannes P. Eggertsson, Sigurjon Axel Gudjonsson, Lucas D. Ward, Gudny A. Arnadottir, Einar A. Helgason, Hannes Helgason, Arnaldur Gylfason, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Thorunn Rafnar, Mike Frigge, Simon N. Stacey, Olafur Th. Magnusson, Unnur Thorsteinsdottir, Gisli Masson, Augustine Kong, Bjarni V. Halldorsson, Agnar Helgason, Daniel F. Gudbjartsson () and Kari Stefansson ()
Additional contact information
Hákon Jónsson: deCODE genetics/Amgen Inc.
Patrick Sulem: deCODE genetics/Amgen Inc.
Birte Kehr: deCODE genetics/Amgen Inc.
Snaedis Kristmundsdottir: deCODE genetics/Amgen Inc.
Florian Zink: deCODE genetics/Amgen Inc.
Eirikur Hjartarson: deCODE genetics/Amgen Inc.
Marteinn T. Hardarson: deCODE genetics/Amgen Inc.
Kristjan E. Hjorleifsson: deCODE genetics/Amgen Inc.
Hannes P. Eggertsson: deCODE genetics/Amgen Inc.
Sigurjon Axel Gudjonsson: deCODE genetics/Amgen Inc.
Lucas D. Ward: deCODE genetics/Amgen Inc.
Gudny A. Arnadottir: deCODE genetics/Amgen Inc.
Einar A. Helgason: deCODE genetics/Amgen Inc.
Hannes Helgason: deCODE genetics/Amgen Inc.
Arnaldur Gylfason: deCODE genetics/Amgen Inc.
Adalbjorg Jonasdottir: deCODE genetics/Amgen Inc.
Aslaug Jonasdottir: deCODE genetics/Amgen Inc.
Thorunn Rafnar: deCODE genetics/Amgen Inc.
Mike Frigge: deCODE genetics/Amgen Inc.
Simon N. Stacey: deCODE genetics/Amgen Inc.
Olafur Th. Magnusson: deCODE genetics/Amgen Inc.
Unnur Thorsteinsdottir: deCODE genetics/Amgen Inc.
Gisli Masson: deCODE genetics/Amgen Inc.
Augustine Kong: deCODE genetics/Amgen Inc.
Bjarni V. Halldorsson: deCODE genetics/Amgen Inc.
Agnar Helgason: deCODE genetics/Amgen Inc.
Daniel F. Gudbjartsson: deCODE genetics/Amgen Inc.
Kari Stefansson: deCODE genetics/Amgen Inc.

Nature, 2017, vol. 549, issue 7673, 519-522

Abstract: Whole-genome sequencing data of 14,688 Icelanders, including 1,548 parent–offspring trios, show how the age and sex of parents affect the rate and spectrum of de novo mutations.

Date: 2017
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DOI: 10.1038/nature24018

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