Alternative evolutionary histories in the sequence space of an ancient protein

Tyler N. Starr, Lora K. Picton and Joseph W. Thornton ()
Additional contact information
Tyler N. Starr: University of Chicago
Lora K. Picton: University of Chicago
Joseph W. Thornton: University of Chicago

Nature, 2017, vol. 549, issue 7672, 409-413

Abstract: Combining ancestral protein reconstruction with deep mutational scanning to characterize alternative histories in the sequence space around an ancient transcription factor reveals hundreds of alternative protein sequences that use diverse biochemical mechanisms to perform the derived function at least as well as the historical outcome.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature23902 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:549:y:2017:i:7672:d:10.1038_nature23902

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature23902

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().