Discovery of stimulation-responsive immune enhancers with CRISPR activation

Dimitre R. Simeonov, Benjamin G. Gowen, Mandy Boontanrart, Theodore L. Roth, John D. Gagnon, Maxwell R. Mumbach, Ansuman T. Satpathy, Youjin Lee, Nicolas L. Bray, Alice Y. Chan, Dmytro S. Lituiev, Michelle L. Nguyen, Rachel E. Gate, Meena Subramaniam, Zhongmei Li, Jonathan M. Woo, Therese Mitros, Graham J. Ray, Gemma L. Curie, Nicki Naddaf, Julia S. Chu, Hong Ma, Eric Boyer, Frederic Van Gool, Hailiang Huang, Ruize Liu, Victoria R. Tobin, Kathrin Schumann, Mark J. Daly, Kyle K. Farh, K. Mark Ansel, Chun J. Ye, William J. Greenleaf, Mark S. Anderson, Jeffrey A. Bluestone, Howard Y. Chang, Jacob E. Corn () and Alexander Marson ()
Additional contact information
Dimitre R. Simeonov: Biomedical Sciences Graduate Program, University of California
Benjamin G. Gowen: Innovative Genomics Institute, University of California
Mandy Boontanrart: Innovative Genomics Institute, University of California
Theodore L. Roth: Biomedical Sciences Graduate Program, University of California
John D. Gagnon: Biomedical Sciences Graduate Program, University of California
Maxwell R. Mumbach: Center for Personal Dynamic Regulomes, Stanford University School of Medicine
Ansuman T. Satpathy: Center for Personal Dynamic Regulomes, Stanford University School of Medicine
Youjin Lee: University of California
Nicolas L. Bray: Innovative Genomics Institute, University of California
Alice Y. Chan: Diabetes Center, University of California
Dmytro S. Lituiev: Institute for Human Genetics (IHG), University of California
Michelle L. Nguyen: University of California
Rachel E. Gate: Institute for Human Genetics (IHG), University of California
Meena Subramaniam: Institute for Human Genetics (IHG), University of California
Zhongmei Li: University of California
Jonathan M. Woo: University of California
Therese Mitros: Innovative Genomics Institute, University of California
Graham J. Ray: Innovative Genomics Institute, University of California
Gemma L. Curie: Innovative Genomics Institute, University of California
Nicki Naddaf: Innovative Genomics Institute, University of California
Julia S. Chu: Innovative Genomics Institute, University of California
Hong Ma: Innovative Genomics Institute, University of California
Eric Boyer: Diabetes Center, University of California
Frederic Van Gool: Diabetes Center, University of California
Hailiang Huang: Broad Institute of MIT and Harvard
Ruize Liu: Broad Institute of MIT and Harvard
Victoria R. Tobin: University of California
Kathrin Schumann: University of California
Mark J. Daly: Broad Institute of MIT and Harvard
Kyle K. Farh: Illumina Inc., 5200 Illumina Way
K. Mark Ansel: University of California
Chun J. Ye: Institute for Human Genetics (IHG), University of California
William J. Greenleaf: Center for Personal Dynamic Regulomes, Stanford University School of Medicine
Mark S. Anderson: Diabetes Center, University of California
Jeffrey A. Bluestone: Diabetes Center, University of California
Howard Y. Chang: Center for Personal Dynamic Regulomes, Stanford University School of Medicine
Jacob E. Corn: Innovative Genomics Institute, University of California
Alexander Marson: University of California

Nature, 2017, vol. 549, issue 7670, 111-115

Abstract: The authors use tiled CRISPR activation for functional enhancer discovery across two autoimmunity risk loci, CD69 and IL2RA, and identify elements with features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours a fine-mapped autoimmunity risk variant.

Date: 2017
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DOI: 10.1038/nature23875

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