The DNA sequence and analysis of human chromosome 14

Roland Heilig (), Ralph Eckenberg, Jean-Louis Petit, Núria Fonknechten, Corinne Da Silva, Laurence Cattolico, Michaël Levy, Valérie Barbe, Véronique de Berardinis, Abel Ureta-Vidal, Eric Pelletier, Virginie Vico, Véronique Anthouard, Lee Rowen, Anup Madan, Shizhen Qin, Hui Sun, Hui Du, Kymberlie Pepin, François Artiguenave, Catherine Robert, Corinne Cruaud, Thomas Brüls, Olivier Jaillon, Lucie Friedlander, Gaelle Samson, Philippe Brottier, Susan Cure, Béatrice Ségurens, Franck Anière, Sylvie Samain, Hervé Crespeau, Nissa Abbasi, Nathalie Aiach, Didier Boscus, Rachel Dickhoff, Monica Dors, Ivan Dubois, Cynthia Friedman, Michel Gouyvenoux, Rose James, Anuradha Madan, Barbara Mairey–Estrada, Sophie Mangenot, Nathalie Martins, Manuela Ménard, Sophie Oztas, Amber Ratcliffe, Tristan Shaffer, Barbara Trask, Benoit Vacherie, Chadia Bellemere, Caroline Belser, Marielle Besnard-Gonnet, Delphine Bartol–Mavel, Magali Boutard, Stéphanie Briez-Silla, Stephane Combette, Virginie Dufossé-Laurent, Carolyne Ferron, Christophe Lechaplais, Claudine Louesse, Delphine Muselet, Ghislaine Magdelenat, Emilie Pateau, Emmanuelle Petit, Peggy Sirvain-Trukniewicz, Arnaud Trybou, Nathalie Vega-Czarny, Elodie Bataille, Elodie Bluet, Isabelle Bordelais, Maria Dubois, Corinne Dumont, Thomas Guérin, Sébastien Haffray, Rachid Hammadi, Jacqueline Muanga, Virginie Pellouin, Dominique Robert, Edith Wunderle, Gilbert Gauguet, Alice Roy, Laurent Sainte-Marthe, Jean Verdier, Claude Verdier-Discala, LaDeana Hillier, Lucinda Fulton, John McPherson, Fumihiko Matsuda, Richard Wilson, Claude Scarpelli, Gábor Gyapay, Patrick Wincker, William Saurin, Francis Quétier, Robert Waterston, Leroy Hood and Jean Weissenbach
Additional contact information
Roland Heilig: Genoscope-Centre National de Séquençage
Ralph Eckenberg: Genoscope-Centre National de Séquençage
Jean-Louis Petit: Genoscope-Centre National de Séquençage
Núria Fonknechten: Genoscope-Centre National de Séquençage
Corinne Da Silva: Genoscope-Centre National de Séquençage
Laurence Cattolico: Genoscope-Centre National de Séquençage
Michaël Levy: Genoscope-Centre National de Séquençage
Valérie Barbe: Genoscope-Centre National de Séquençage
Véronique de Berardinis: Genoscope-Centre National de Séquençage
Abel Ureta-Vidal: Genoscope-Centre National de Séquençage
Eric Pelletier: Genoscope-Centre National de Séquençage
Virginie Vico: Genoscope-Centre National de Séquençage
Véronique Anthouard: Genoscope-Centre National de Séquençage
Lee Rowen: Institute for Systems Biology
Anup Madan: Institute for Systems Biology
Shizhen Qin: Institute for Systems Biology
Hui Sun: Genome Sequencing Center, Washington University School of Medicine
Hui Du: Genome Sequencing Center, Washington University School of Medicine
Kymberlie Pepin: Genome Sequencing Center, Washington University School of Medicine
François Artiguenave: Genoscope-Centre National de Séquençage
Catherine Robert: Genoscope-Centre National de Séquençage
Corinne Cruaud: Genoscope-Centre National de Séquençage
Thomas Brüls: Genoscope-Centre National de Séquençage
Olivier Jaillon: Genoscope-Centre National de Séquençage
Lucie Friedlander: Genoscope-Centre National de Séquençage
Gaelle Samson: Genoscope-Centre National de Séquençage
Philippe Brottier: Genoscope-Centre National de Séquençage
Susan Cure: Genoscope-Centre National de Séquençage
Béatrice Ségurens: Genoscope-Centre National de Séquençage
Franck Anière: Genoscope-Centre National de Séquençage
Sylvie Samain: Genoscope-Centre National de Séquençage
Hervé Crespeau: Genoscope-Centre National de Séquençage
Nissa Abbasi: Institute for Systems Biology
Nathalie Aiach: Genoscope-Centre National de Séquençage
Didier Boscus: Genoscope-Centre National de Séquençage
Rachel Dickhoff: Institute for Systems Biology
Monica Dors: Institute for Systems Biology
Ivan Dubois: Genoscope-Centre National de Séquençage
Cynthia Friedman: Institute for Systems Biology
Michel Gouyvenoux: Genoscope-Centre National de Séquençage
Rose James: Institute for Systems Biology
Anuradha Madan: Institute for Systems Biology
Barbara Mairey–Estrada: Genoscope-Centre National de Séquençage
Sophie Mangenot: Genoscope-Centre National de Séquençage
Nathalie Martins: Genoscope-Centre National de Séquençage
Manuela Ménard: Genoscope-Centre National de Séquençage
Sophie Oztas: Genoscope-Centre National de Séquençage
Amber Ratcliffe: Institute for Systems Biology
Tristan Shaffer: Institute for Systems Biology
Barbara Trask: Institute for Systems Biology
Benoit Vacherie: Genoscope-Centre National de Séquençage
Chadia Bellemere: Genoscope-Centre National de Séquençage
Caroline Belser: Genoscope-Centre National de Séquençage
Marielle Besnard-Gonnet: Genoscope-Centre National de Séquençage
Delphine Bartol–Mavel: Genoscope-Centre National de Séquençage
Magali Boutard: Genoscope-Centre National de Séquençage
Stéphanie Briez-Silla: Genoscope-Centre National de Séquençage
Stephane Combette: Genoscope-Centre National de Séquençage
Virginie Dufossé-Laurent: Genoscope-Centre National de Séquençage
Carolyne Ferron: Genoscope-Centre National de Séquençage
Christophe Lechaplais: Genoscope-Centre National de Séquençage
Claudine Louesse: Genoscope-Centre National de Séquençage
Delphine Muselet: Genoscope-Centre National de Séquençage
Ghislaine Magdelenat: Genoscope-Centre National de Séquençage
Emilie Pateau: Genoscope-Centre National de Séquençage
Emmanuelle Petit: Genoscope-Centre National de Séquençage
Peggy Sirvain-Trukniewicz: Genoscope-Centre National de Séquençage
Arnaud Trybou: Genoscope-Centre National de Séquençage
Nathalie Vega-Czarny: Genoscope-Centre National de Séquençage
Elodie Bataille: Genoscope-Centre National de Séquençage
Elodie Bluet: Genoscope-Centre National de Séquençage
Isabelle Bordelais: Genoscope-Centre National de Séquençage
Maria Dubois: Genoscope-Centre National de Séquençage
Corinne Dumont: Genoscope-Centre National de Séquençage
Thomas Guérin: Genoscope-Centre National de Séquençage
Sébastien Haffray: Genoscope-Centre National de Séquençage
Rachid Hammadi: Genoscope-Centre National de Séquençage
Jacqueline Muanga: Genoscope-Centre National de Séquençage
Virginie Pellouin: Genoscope-Centre National de Séquençage
Dominique Robert: Genoscope-Centre National de Séquençage
Edith Wunderle: Genoscope-Centre National de Séquençage
Gilbert Gauguet: Genoscope-Centre National de Séquençage
Alice Roy: Genoscope-Centre National de Séquençage
Laurent Sainte-Marthe: Genoscope-Centre National de Séquençage
Jean Verdier: Genoscope-Centre National de Séquençage
Claude Verdier-Discala: Genoscope-Centre National de Séquençage
LaDeana Hillier: Genome Sequencing Center, Washington University School of Medicine
Lucinda Fulton: Genome Sequencing Center, Washington University School of Medicine
John McPherson: Genome Sequencing Center, Washington University School of Medicine
Fumihiko Matsuda: Centre National de Génotypage
Richard Wilson: Genome Sequencing Center, Washington University School of Medicine
Claude Scarpelli: Genoscope-Centre National de Séquençage
Gábor Gyapay: Genoscope-Centre National de Séquençage
Patrick Wincker: Genoscope-Centre National de Séquençage
William Saurin: Genoscope-Centre National de Séquençage
Francis Quétier: Genoscope-Centre National de Séquençage
Robert Waterston: Genome Sequencing Center, Washington University School of Medicine
Leroy Hood: Institute for Systems Biology
Jean Weissenbach: Genoscope-Centre National de Séquençage

Nature, 2003, vol. 421, issue 6923, 601-607

Abstract: Abstract Chromosome 14 is one of five acrocentric chromosomes in the human genome. These chromosomes are characterized by a heterochromatic short arm that contains essentially ribosomal RNA genes, and a euchromatic long arm in which most, if not all, of the protein-coding genes are located. The finished sequence of human chromosome 14 comprises 87,410,661 base pairs, representing 100% of its euchromatic portion, in a single continuous segment covering the entire long arm with no gaps. Two loci of crucial importance for the immune system, as well as more than 60 disease genes, have been localized so far on chromosome 14. We identified 1,050 genes and gene fragments, and 393 pseudogenes. On the basis of comparisons with other vertebrate genomes, we estimate that more than 96% of the chromosome 14 genes have been annotated. From an analysis of the CpG island occurrences, we estimate that 70% of these annotated genes are complete at their 5′ end.

Date: 2003
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DOI: 10.1038/nature01348

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