Improved reference genome of Aedes aegypti informs arbovirus vector control

Matthews, Benjamin J.; Dudchenko, Olga; Kingan, Sarah B.; Koren, Sergey; Antoshechkin, Igor; Crawford, Jacob E.; Glassford, William J.; Herre, Margaret; Redmond, Seth N.; Rose, Noah H.; Weedall, Gareth D.; Wu, Yang; Batra, Sanjit S.; Brito-Sierra, Carlos A.; Buckingham, Steven D.; Campbell, Corey L.; Chan, Saki; Cox, Eric; Evans, Benjamin R.; Fansiri, Thanyalak; Filipović, Igor; Fontaine, Albin; Gloria-Soria, Andrea; Hall, Richard; Joardar, Vinita S.; Jones, Andrew K.; Kay, Raissa G. G.; Kodali, Vamsi K.; Lee, Joyce; Lycett, Gareth J.; Mitchell, Sara N.; Muehling, Jill; Murphy, Michael R.; Omer, Arina D.; Partridge, Frederick A.; Peluso, Paul; Aiden, Aviva Presser; Ramasamy, Vidya; Rašić, Gordana; Roy, Sourav; Saavedra-Rodriguez, Karla; Sharan, Shruti; Sharma, Atashi; Smith, Melissa Laird; Turner, Joe; Weakley, Allison M.; Zhao, Zhilei; Akbari, Omar S.; Black, William C.; Cao, Han; Darby, Alistair C.; Hill, Catherine A.; Johnston, J. Spencer; Murphy, Terence D.; Raikhel, Alexander S.; Sattelle, David B.; Sharakhov, Igor V.; White, Bradley J.; Zhao, Li; Aiden, Erez Lieberman; Mann, Richard S.; Lambrechts, Louis; Powell, Jeffrey R.; Sharakhova, Maria V.; Tu, Zhijian; Robertson, Hugh M.; McBride, Carolyn S.; Hastie, Alex R.; Korlach, Jonas; Neafsey, Daniel E.; Phillippy, Adam M.; Vosshall, Leslie B.

Improved reference genome of Aedes aegypti informs arbovirus vector control

Benjamin J. Matthews (), Olga Dudchenko, Sarah B. Kingan, Sergey Koren, Igor Antoshechkin, Jacob E. Crawford, William J. Glassford, Margaret Herre, Seth N. Redmond, Noah H. Rose, Gareth D. Weedall, Yang Wu, Sanjit S. Batra, Carlos A. Brito-Sierra, Steven D. Buckingham, Corey L. Campbell, Saki Chan, Eric Cox, Benjamin R. Evans, Thanyalak Fansiri, Igor Filipović, Albin Fontaine, Andrea Gloria-Soria, Richard Hall, Vinita S. Joardar, Andrew K. Jones, Raissa G. G. Kay, Vamsi K. Kodali, Joyce Lee, Gareth J. Lycett, Sara N. Mitchell, Jill Muehling, Michael R. Murphy, Arina D. Omer, Frederick A. Partridge, Paul Peluso, Aviva Presser Aiden, Vidya Ramasamy, Gordana Rašić, Sourav Roy, Karla Saavedra-Rodriguez, Shruti Sharan, Atashi Sharma, Melissa Laird Smith, Joe Turner, Allison M. Weakley, Zhilei Zhao, Omar S. Akbari, William C. Black, Han Cao, Alistair C. Darby, Catherine A. Hill, J. Spencer Johnston, Terence D. Murphy, Alexander S. Raikhel, David B. Sattelle, Igor V. Sharakhov, Bradley J. White, Li Zhao, Erez Lieberman Aiden, Richard S. Mann, Louis Lambrechts, Jeffrey R. Powell, Maria V. Sharakhova, Zhijian Tu, Hugh M. Robertson, Carolyn S. McBride, Alex R. Hastie, Jonas Korlach, Daniel E. Neafsey, Adam M. Phillippy and Leslie B. Vosshall
Additional contact information
Benjamin J. Matthews: The Rockefeller University
Olga Dudchenko: Baylor College of Medicine
Sarah B. Kingan: Pacific Biosciences
Sergey Koren: National Human Genome Research Institute, National Institutes of Health
Igor Antoshechkin: California Institute of Technology
Jacob E. Crawford: Verily Life Sciences
William J. Glassford: Columbia University
Margaret Herre: The Rockefeller University
Seth N. Redmond: Broad Institute of MIT and Harvard
Noah H. Rose: Princeton University
Gareth D. Weedall: Liverpool School of Tropical Medicine
Yang Wu: Southern Medical University
Sanjit S. Batra: Baylor College of Medicine
Carlos A. Brito-Sierra: Purdue University
Steven D. Buckingham: University College London
Corey L. Campbell: Colorado State University
Saki Chan: Bionano Genomics
Eric Cox: National Institutes of Health
Benjamin R. Evans: Yale University
Thanyalak Fansiri: Armed Forces Research Institute of Medical Sciences (AFRIMS)
Igor Filipović: QIMR Berghofer Medical Research Institute
Albin Fontaine: Institut Pasteur
Andrea Gloria-Soria: Yale University
Richard Hall: Pacific Biosciences
Vinita S. Joardar: National Institutes of Health
Andrew K. Jones: Oxford Brookes University
Raissa G. G. Kay: University of California Riverside
Vamsi K. Kodali: National Institutes of Health
Joyce Lee: Bionano Genomics
Gareth J. Lycett: Liverpool School of Tropical Medicine
Sara N. Mitchell: Verily Life Sciences
Jill Muehling: Pacific Biosciences
Michael R. Murphy: National Institutes of Health
Arina D. Omer: Baylor College of Medicine
Frederick A. Partridge: University College London
Paul Peluso: Pacific Biosciences
Aviva Presser Aiden: Baylor College of Medicine
Vidya Ramasamy: Oxford Brookes University
Gordana Rašić: QIMR Berghofer Medical Research Institute
Sourav Roy: University of California
Karla Saavedra-Rodriguez: Colorado State University
Shruti Sharan: Purdue University
Atashi Sharma: Virginia Tech
Melissa Laird Smith: Pacific Biosciences
Joe Turner: University of Liverpool
Allison M. Weakley: Verily Life Sciences
Zhilei Zhao: Princeton University
Omar S. Akbari: University of California, San Diego
William C. Black: Colorado State University
Han Cao: Bionano Genomics
Alistair C. Darby: University of Liverpool
Catherine A. Hill: Purdue University
J. Spencer Johnston: Texas A&M University
Terence D. Murphy: National Institutes of Health
Alexander S. Raikhel: University of California
David B. Sattelle: University College London
Igor V. Sharakhov: Virginia Tech
Bradley J. White: Verily Life Sciences
Li Zhao: The Rockefeller University
Erez Lieberman Aiden: Baylor College of Medicine
Richard S. Mann: Columbia University
Louis Lambrechts: Institut Pasteur
Jeffrey R. Powell: Yale University
Maria V. Sharakhova: Virginia Tech
Zhijian Tu: Virginia Tech
Hugh M. Robertson: University of Illinois at Urbana-Champaign
Carolyn S. McBride: Princeton University
Alex R. Hastie: Bionano Genomics
Jonas Korlach: Pacific Biosciences
Daniel E. Neafsey: Broad Institute of MIT and Harvard
Adam M. Phillippy: National Human Genome Research Institute, National Institutes of Health
Leslie B. Vosshall: The Rockefeller University

Nature, 2018, vol. 563, issue 7732, 501-507

Abstract: Abstract Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.

Keywords: Mosquito; Primary Contigs; Predicted Transcription Start Site; Aegypti Genome; Nano Bio (search for similar items in EconPapers)
Date: 2018
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Citations: View citations in EconPapers (3)

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DOI: 10.1038/s41586-018-0692-z

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