The structural basis of agonist-induced activation in constitutively active rhodopsin

Jörg Standfuss, Patricia C. Edwards, Aaron D’Antona, Maikel Fransen, Guifu Xie, Daniel D. Oprian and Gebhard F. X. Schertler ()
Additional contact information
Jörg Standfuss: Paul Scherrer Institut
Patricia C. Edwards: MRC Laboratory of Molecular Biology
Aaron D’Antona: Brandeis University
Maikel Fransen: Paul Scherrer Institut
Guifu Xie: Brandeis University
Daniel D. Oprian: Brandeis University
Gebhard F. X. Schertler: Paul Scherrer Institut

Nature, 2011, vol. 471, issue 7340, 656-660

Abstract: Rhodopsin activation Structural studies of active states of the visual pigment rhodopsin, a G protein-coupled receptor, have previously been limited to apoprotein or opsin forms that do not contain the agonist all-trans-retinal. Two groups now report structures that reveal more details of the transformations involved in rhodopsin activation. Choe et al. solve the X-ray crystal structure of the metarhodopsin II intermediate of the photoreceptor rhodopsin, and Standfuss et al. determine the structure of a constitutively active mutant of rhodopsin bound to a peptide derived from the C-terminus of the G protein transducin.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature09795 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:471:y:2011:i:7340:d:10.1038_nature09795

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09795

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().