Chromosome length influences replication-induced topological stress

Andreas Kegel, Hanna Betts-Lindroos, Takaharu Kanno, Kristian Jeppsson, Lena Ström, Yuki Katou, Takehiko Itoh, Katsuhiko Shirahige and Camilla Sjögren ()
Additional contact information
Andreas Kegel: Karolinska Institutet, von Eulers väg 3
Hanna Betts-Lindroos: Karolinska Institutet, von Eulers väg 3
Takaharu Kanno: Karolinska Institutet, von Eulers väg 3
Kristian Jeppsson: Karolinska Institutet, von Eulers väg 3
Lena Ström: Karolinska Institutet, von Eulers väg 3
Yuki Katou: Laboratory of In Silico Functional Genomics, Graduate School of Bioscience, Tokyo Institute of Technology, 4259 Nagatsuta
Takehiko Itoh: Laboratory of In Silico Functional Genomics, Graduate School of Bioscience, Tokyo Institute of Technology, 4259 Nagatsuta
Katsuhiko Shirahige: Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi
Camilla Sjögren: Karolinska Institutet, von Eulers väg 3

Nature, 2011, vol. 471, issue 7338, 392-396

Abstract: Stress relief for chromosomes As the replication fork progresses along parental DNA during chromosome replication, there is a build-up of topological stress ahead of the polymerase. Current models propose that linear eukaryotic chromosomes are divided into topological domains, and that stress is relieved by the activity of a topoisomerase. Camilla Sjögren and colleagues find that replication stress is present throughout the chromosome, and that the relief of stress in longer chromosomes is facilitated by the activity of the cohesin/condensin-like Smc5/6 complex as well as by topoisomerase. They propose that the Smc5/6 complex prevent formation of topological tension ahead of the replication fork by promoting fork rotation, leading to the formation of sister chromatin intertwinings behind.

Date: 2011
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature09791 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:471:y:2011:i:7338:d:10.1038_nature09791

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09791

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().