CREBBP mutations in relapsed acute lymphoblastic leukaemia

Charles G. Mullighan (), Jinghui Zhang, Lawryn H. Kasper, Stephanie Lerach, Debbie Payne-Turner, Letha A. Phillips, Sue L. Heatley, Linda Holmfeldt, J. Racquel Collins-Underwood, Jing Ma, Kenneth H. Buetow, Ching-Hon Pui, Sharyn D. Baker, Paul K. Brindle and James R. Downing
Additional contact information
Charles G. Mullighan: St Jude Children’s Research Hospital
Jinghui Zhang: St Jude Children’s Research Hospital
Lawryn H. Kasper: St Jude Children’s Research Hospital
Stephanie Lerach: St Jude Children’s Research Hospital
Debbie Payne-Turner: St Jude Children’s Research Hospital
Letha A. Phillips: St Jude Children’s Research Hospital
Sue L. Heatley: St Jude Children’s Research Hospital
Linda Holmfeldt: St Jude Children’s Research Hospital
J. Racquel Collins-Underwood: St Jude Children’s Research Hospital
Jing Ma: The Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital
Kenneth H. Buetow: National Cancer Institute Center for Bioinformatics, National Cancer Institute
Ching-Hon Pui: St Jude Children’s Research Hospital
Sharyn D. Baker: St Jude Children’s Research Hospital
Paul K. Brindle: St Jude Children’s Research Hospital
James R. Downing: St Jude Children’s Research Hospital

Nature, 2011, vol. 471, issue 7337, 235-239

Abstract: CREBBP and EP300 mutations in B-cell lymphoma In three different subtypes of B-cell lymphomas, two papers report frequent somatic mutations in the genes CREBBP and EP300, which are present in primary tumours or acquired at relapse. These genes encode related acetyltransferases that mainly function to regulate gene expression by acetylating histones and other transcriptional regulators. The mutations disrupt these activities and thus alter chromatin regulation of gene expression, as well as proliferation and potentially the response to anticancer drugs. These studies may provide a rationale for the use of histone deacetylase inhibitors in certain B-cell lymphomas.

Date: 2011
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DOI: 10.1038/nature09727

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