In vitro production of functional sperm in cultured neonatal mouse testes

Takuya Sato, Kumiko Katagiri, Ayako Gohbara, Kimiko Inoue, Narumi Ogonuki, Atsuo Ogura, Yoshinobu Kubota and Takehiko Ogawa ()
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Takuya Sato: Yokohama City University Graduate School of Medicine
Kumiko Katagiri: Yokohama City University Graduate School of Medicine
Ayako Gohbara: Yokohama City University Graduate School of Medicine
Kimiko Inoue: RIKEN, Bioresource Center
Narumi Ogonuki: RIKEN, Bioresource Center
Atsuo Ogura: RIKEN, Bioresource Center
Yoshinobu Kubota: Yokohama City University Graduate School of Medicine
Takehiko Ogawa: Yokohama City University Graduate School of Medicine

Nature, 2011, vol. 471, issue 7339, 504-507

Abstract: Preserving sperm fertility Reproducing the complex process of spermatogenesis in vitro might lead to the development of new diagnostic and therapeutic techniques for male infertility. Takehiko Ogawa and colleagues have now established in vitro organ culture conditions that can support the production of fertile sperm from spermatogonia of neonatal mice. Spermatids and sperm that were derived in vitro produced healthy and fertile mice. In addition, neonatal testis tissues that were cryopreserved for several months resumed complete spermatogenesis in vitro on thawing. The organ culture method is simple and, with further refinements, could be applicable to a variety of mammalian species. This work suggests that cryopreservation of the testis tissue of paediatric cancer patients could become a practical way of ensuring future fertility.

Date: 2011
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DOI: 10.1038/nature09850

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