An immunogenic personal neoantigen vaccine for patients with melanoma

Patrick A. Ott, Zhuting Hu, Derin B. Keskin, Sachet A. Shukla, Jing Sun, David J. Bozym, Wandi Zhang, Adrienne Luoma, Anita Giobbie-Hurder, Lauren Peter, Christina Chen, Oriol Olive, Todd A. Carter, Shuqiang Li, David J. Lieb, Thomas Eisenhaure, Evisa Gjini, Jonathan Stevens, William J. Lane, Indu Javeri, Kaliappanadar Nellaiappan, Andres M. Salazar, Heather Daley, Michael Seaman, Elizabeth I. Buchbinder, Charles H. Yoon, Maegan Harden, Niall Lennon, Stacey Gabriel, Scott J. Rodig, Dan H. Barouch, Jon C. Aster, Gad Getz, Kai Wucherpfennig, Donna Neuberg, Jerome Ritz, Eric S. Lander, Edward F. Fritsch, Nir Hacohen and Catherine J. Wu ()
Additional contact information
Patrick A. Ott: Dana-Farber Cancer Institute
Zhuting Hu: Dana-Farber Cancer Institute
Derin B. Keskin: Dana-Farber Cancer Institute
Sachet A. Shukla: Dana-Farber Cancer Institute
Jing Sun: Dana-Farber Cancer Institute
David J. Bozym: Dana-Farber Cancer Institute
Wandi Zhang: Dana-Farber Cancer Institute
Adrienne Luoma: Dana-Farber Cancer Institute
Anita Giobbie-Hurder: Dana-Farber Cancer Institute
Lauren Peter: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
Christina Chen: Dana-Farber Cancer Institute
Oriol Olive: Dana-Farber Cancer Institute
Todd A. Carter: Broad Institute of MIT and Harvard
Shuqiang Li: Broad Institute of MIT and Harvard
David J. Lieb: Broad Institute of MIT and Harvard
Thomas Eisenhaure: Broad Institute of MIT and Harvard
Evisa Gjini: Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute
Jonathan Stevens: Brigham and Women’s Hospital
William J. Lane: Brigham and Women’s Hospital
Indu Javeri: CuriRx, Inc.
Kaliappanadar Nellaiappan: CuriRx, Inc.
Andres M. Salazar: Oncovir, Inc.
Heather Daley: Dana-Farber Cancer Institute
Michael Seaman: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
Elizabeth I. Buchbinder: Dana-Farber Cancer Institute
Charles H. Yoon: Harvard Medical School
Maegan Harden: Broad Institute of MIT and Harvard
Niall Lennon: Broad Institute of MIT and Harvard
Stacey Gabriel: Broad Institute of MIT and Harvard
Scott J. Rodig: Center for Immuno-Oncology (CIO), Dana-Farber Cancer Institute
Dan H. Barouch: Harvard Medical School
Jon C. Aster: Harvard Medical School
Gad Getz: Harvard Medical School
Kai Wucherpfennig: Harvard Medical School
Donna Neuberg: Dana-Farber Cancer Institute
Jerome Ritz: Dana-Farber Cancer Institute
Eric S. Lander: Harvard Medical School
Edward F. Fritsch: Dana-Farber Cancer Institute
Nir Hacohen: Harvard Medical School
Catherine J. Wu: Dana-Farber Cancer Institute

Nature, 2017, vol. 547, issue 7662, 217-221

Abstract: The results of a phase I trial assessing a personal neoantigen multi-peptide vaccine in patients with melanoma, showing feasibility, safety, and immunogenicity.

Date: 2017
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DOI: 10.1038/nature22991

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