RNase III nucleases from diverse kingdoms serve as antiviral effectors

Lauren C. Aguado, Sonja Schmid, Jared May, Leah R. Sabin, Maryline Panis, Daniel Blanco-Melo, Jaehee V. Shim, David Sachs, Sara Cherry, Anne E. Simon, Jean-Pierre Levraud and Benjamin R. tenOever ()
Additional contact information
Lauren C. Aguado: Icahn School of Medicine at Mount Sinai
Sonja Schmid: Icahn School of Medicine at Mount Sinai
Jared May: University of Maryland College Park
Leah R. Sabin: University of Pennsylvania
Maryline Panis: Icahn School of Medicine at Mount Sinai
Daniel Blanco-Melo: Icahn School of Medicine at Mount Sinai
Jaehee V. Shim: Icahn School of Medicine at Mount Sinai
David Sachs: Icahn School of Medicine at Mount Sinai
Sara Cherry: University of Pennsylvania
Anne E. Simon: University of Maryland College Park
Jean-Pierre Levraud: Macrophages et Développement de l’Immunité, Institut Pasteur, CNRS UMR3738
Benjamin R. tenOever: Icahn School of Medicine at Mount Sinai

Nature, 2017, vol. 547, issue 7661, 114-117

Abstract: RNase III from all three domains of life elicits RNA-targeting antiviral activity that is independent of, and possibly predates, other known eukaryotic antiviral systems.

Date: 2017
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DOI: 10.1038/nature22990

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